Mouse nodal, a member of the TGFβ family of secreted growth factors is essential for
gastrulation. We recently generated a nodal lacZ reporter allele by homologous recombination in …

The dengue virus (DV) is an important human pathogen from the Flavivirus genus, whose
genome- and antigenome RNAs start with the strictly conserved sequence pppAG. The RNA-…

Left ventricular non-compaction (LVNC) is a rare cardiomyopathy associated with a
hypertrabeculated phenotype and a large spectrum of symptoms. It is still unclear whether LVNC …

The Rev3 gene of Saccharomyces cerevisiae encodes the catalytic subunit of DNA polymerase
ζ that is implicated in mutagenic translesion synthesis of damaged DNA. To investigate …

All vertebrates develop with a distinct, invariant, left—right (L—R) body asymmetry. Recently,
a number of molecules have been shown to be expressed asymmetrically with respect to …

The yeast Set1 histone H3 lysine 4 (H3K4) methyltransferase contains, in addition to its
catalytic SET domain, a conserved RNA recognition motif (RRM1). We present here the crystal …

Little is known about the molecular mechanisms that integrate anteroposterior (AP) and
dorsoventral (DV) positional information in neural progenitors that specify distinct neuronal types …

A series of 10 derivatives 2–6 issued from the fusion of various five-membered heterocycles
to cyclopenta[c]thiophene were evaluated for potential anticancer activity in the NCI's in vitro …

In budding yeast, the cortical structure formed by the septins is remodeled at the onset of
mitotic exit and delineates a specialized compartment dedicated to cytokinesis. How this septin …

Repair of all 12 single base-pair mismatches by Xenopus egg extracts was measured by a
physical assay with a sequence containing four overlapping restriction sites. The …