Dnmt3a knockout in excitatory neurons impairs postnatal synapse maturation and increases the repressive histone modification H3K27me3

…, R Gomez-Castanon, JR Nery, I Silva-Garcia… - Elife, 2022 - elifesciences.org
Two epigenetic pathways of transcriptional repression, DNA methylation and polycomb
repressive complex 2 (PRC2), are known to regulate neuronal development and function. …

Polycomb-mediated repression compensates for loss of postnatal DNA methylation in excitatory neurons

…, R Gomez-Castanon, JR Nery, I Silva-Garcia… - BioRxiv, 2019 - biorxiv.org
Epigenetic modifications of DNA regulate gene expression throughout the lifespan in neurons.
Two major epigenetic pathways of repression, DNA methylation and Polycomb repressive …

Early life experience drives structural variation of neural genomes in mice

TA Bedrosian, C Quayle, N Novaresi, FH Gage - Science, 2018 - science.org
The brain is a genomic mosaic owing to somatic mutations that arise throughout
development. Mobile genetic elements, including retrotransposons, are one source of somatic …

Inhibiting effects of dietary polyphenols on chronic eye diseases

Z Xu, T Sun, W Li, X Sun - Journal of Functional Foods, 2017 - Elsevier
The prevalence of many eye diseases, including cataracts, age-related macular degeneration
and diabetic retinopathy, is expected to increase and has become leading causes of …

Geração, fluxo e uso da informação em ocupações de agências de turismo do Rio de Janeiro: estudo preliminar

AG Luengo Medina - 1991 - pantheon.ufrj.br
… Pereira Bosisio Ana Lõcia da Silva Garcia Angflica Vasquez Antonio Areias Armando de …
ma isai nd a quando os modelos ut ili zados corr espondem às ci ênc i as soc iais de mane i …

[BOOK][B] Die Ummöglichkeit der Emanzipation der Juden im christlichen Staate

WB Fränkel - 1842 - books.google.com
… ) zurückführen, und will sie herstellen, wie zuvor, und will ſie reinigen von ihrer Missethat (von
ihrer Pariaschaft) und zwar durch den Sohn Davids, durch den Zweig des Stammes Isai," …

Avaliação do desempenho de colírio usando soro alogênico e fatores de crescimento derivados de plaquetas em cultura de células do anel córneo-escleral

JRB Martins - 2014 - repositorio.unesp.br
Introdução: Muitas patologias podem acometer a córnea, entre elas a síndrome do olho
seco e as doenças relacionadas. Tratamentos inovadores para a síndrome do olho seco têm …