New genetic loci link adipose and insulin biology to body fat distribution

…, W Koenig, IK Kooner, W Kratzer, C Lamina, K Leander… - Nature, 2015 - nature.com
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …

The trans-ancestral genomic architecture of glycemic traits

…, KA Kentistou, YJ Kim, ME Kleber, IK Kooner… - Nature …, 2021 - nature.com
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health.
To date, most genetic studies of glycemic traits have focused on individuals of European …

52 genetic loci influencing myocardial mass

…, M Kellis, I Kolcic, IK Kooner, JS Kooner… - Journal of the American …, 2016 - jacc.org
Background : Myocardial mass is a key determinant of cardiac muscle function and
hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the …

[HTML][HTML] A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

…, PB Knekt, HA Koistinen, I Kolcic, IK Kooner… - Nature …, 2016 - nature.com
Large consortia have revealed hundreds of genetic loci associated with anthropometric traits,
one trait at a time. We examined whether genetic variants affect body shape as a …

[HTML][HTML] The south Asian genome

…, MN Wass, K Miller, J Sehmi, L Oozageer, IK Kooner… - PloS one, 2014 - journals.plos.org
The genetic sequence variation of people from the Indian subcontinent who comprise one-quarter
of the world's population, is not well described. We carried out whole genome …

[PDF][PDF] Fifty-two genetic loci influencing myocardial mass

PB MUNROE - Journal of the American College of Cardiology, 2016 - qmro.qmul.ac.uk
BACKGROUND: Myocardial mass is a key determinant of cardiac muscle function and
hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the …

Change in platelet levels during radiotherapy with concurrent and adjuvant temozolomide for the treatment of glioblastoma: a novel prognostic factor for survival

…, V Michalarea, R Menashy, I Kooner… - Journal of cancer …, 2012 - Springer
Background Radiotherapy plus concomitant and adjuvant temozolomide (RCAT) is now
standard treatment for grade IV glioblastoma (GBM). We report the results from our 7 years …

Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH

JH Li, LN Brenner, V Kaur, K Figueroa, P Schroeder… - Diabetologia, 2023 - Springer
Aims/hypothesis Characterisation of genetic variation that influences the response to
glucose-lowering medications is instrumental to precision medicine for treatment of type 2 diabetes. …

[HTML][HTML] Life style, perfusion deficits and co-morbidities precipitate inflammation and cerebrovascular disorders in aged subjects

A Uzoni, O Ciobanu, RE Sandu, AM Buga… - Discoveries, 2015 - ncbi.nlm.nih.gov
Cerebrovascular diseases represent 2nd leading cause of death worldwide. Understanding
how genetic predispositions and their interaction with environmental factors affect …

[HTML][HTML] Repeat Elements and Novel Genes Contribute to Sex-Specific Mechanisms of Metabolism

G Hansen - 2021 - search.proquest.com
Obesity-associated mortality is exacerbated by high abdominal obesity. Here, we identify
genes associated with obesity and waist-to-hip ratio adjusted for body mass index (WHRadjBMI…