The International Collaboration in Asthma, Allergy and Immunology initiated an international
coalition among the American Academy of Allergy, Asthma & Immunology; the European …

BACKGROUND: The genetic etiologies of the hyper-IgE syndromes are diverse. Approximately
60% to 70% of patients with hyper-IgE syndrome have dominant mutations in STAT3, …

Background Chronic granulomatous disease (CGD) is a rare primary immunodeficiency
disorder of phagocytes resulting in impaired killing of bacteria and fungi. A mutation in one of …

Class IA phosphatidylinositol 3-kinases (PI3K), which generate PIP 3 as a signal for cell
growth and proliferation, exist as an intracellular complex of a catalytic subunit bound to a …

The adaptors DOCK8 and MyD88 have been linked to serological memory. Here we report
that DOCK8-deficient patients had impaired antibody responses and considerably fewer …

To evaluate the efficacy of specific sublingual immunotherapy (SLIT), we enrolled 15 children
with asthma and rhinitis (7 girls, 8 boys,mean ± SD age of 11.7 ± 3.3) allergic to house dust …

BACKGROUND: The role of topical corticosteroids in the treatment of acute sinusitis has not
been established in children. OBJECTIVE: An attempt was made to determine the impact of …

Objective: To evaluate the clinical outcome and changes in allergen-specific antibodies during
sublingual immunotherapy (SLIT) in house dust mite (HDM)-allergic asthma patients and …

BACKGROUND: Subcutaneous allergen-specific immunotherapy (SIT) has an early onset of
action, whereas repeated injections and safety concerns have limited its use in the pediatric …

Background Chronic granulomatous disease (CGD) is a rare primary immunodeficiency caused
by inborn errors of the phagocyte nicotinamide adenine dinucleotide phosphate oxidase …