Human tumor xenograft models do not replicate the human immune system and tumor
microenvironment. We developed an improved humanized mouse model, derived from fresh cord …

Functionalization of nanoparticles with cationic moieties, such as polyethyleneimine (PEI),
enhances binding to the cell membrane; however, it also disrupts the integrity of the cell's …

Dendritic cells (DC) process and present antigens to T lymphocytes, inducing potent immune
responses when encountered in association with activating signals, such as pathogen-…

Expression of the multikinase inhibitor encoded by the tumor suppressor gene TUSC2 (also
known as FUS1) is lost or decreased in non–small cell lung carcinoma (NSCLC). TUSC2 …

Porous silicon microparticles presenting pathogen-associated molecular patterns mimic
pathogens, enhancing internalization of the microparticles and activation of antigen presenting …

KRAS/LKB1 (STK11) NSCLC metastatic tumors are intrinsically resistant to anti-PD-1 or PD-L1
immunotherapy. In this study, we use a humanized mouse model to show that while …

Background Enteropathogens cannot be identified in 40% to 50% of subjects with travelers’
diarrhea (TD). Methods We used polymerase chain reaction (PCR) methods to look for the …

Porous silicon (pSi) microparticles, in diverse sizes and shapes, can be functionalized to
present pathogen-associated molecular patterns that activate dendritic cells. Intraperitoneal …

Targeted therapy is effective in many tumor types including lung cancer, the leading cause
of cancer mortality. Paradigm defining examples are targeted therapies directed against non-…

Immunotherapies targeting immune checkpoints have proven efficacious in reducing the
burden of lung cancer in patients; however, the antigenic targets of these reinvigorated T cells …