Activation of Agouti-related peptide (AgRP) neurons potently promotes feeding, and chronically
altering their activity also affects peripheral glucose homeostasis. We demonstrate that …

Nucleotide excision repair (NER) is a major DNA repair pathway that ensures that the genome
remains functionally intact and is faithfully transmitted to progeny. However, defects in …

To counteract DNA damage, cells employ genome maintenance pathways that are directed
inward, relentlessly to scan and repair the genome. Adaptive and innate immune …

Lipodystrophies represent a group of heterogeneous disorders characterized by loss of fat
tissue. However, the underlying mechanisms remain poorly understood. Using mice carrying …

Low-grade inflammation links obesity to insulin resistance through the activation of tissue-infiltrating
immune cells. Interleukin-6 (IL-6) is a crucial regulator of T cells and is increased in …

Dear Editor, The role of RNA silencing in antiviral plant defense is rather well studied. In
contrast, the role of RNA silencing pathways on viroids’ biological cycle is still unclear. Viroids …

10.7554/eLife.25770.001 In the arcuate nucleus of the hypothalamus (ARH) satiety
signaling (anorexigenic) pro-opiomelanocortin (POMC)-expressing and hunger signaling (orexigenic…

Nucleotide excision repair (NER) defects are associated with cancer, developmental disorders
and neurodegeneration. However, with the exception of cancer, the links between defects …

Inborn defects in DNA repair are associated with complex developmental disorders whose
causal mechanisms are poorly understood. Using an in vivo biotinylation tagging approach in …

… Ismene Karakasilioti 1, 2 and George A. Garinis 1, 2 … Recent work from our lab allowed
us to gain further insights on how random DNA damage events could trigger the onset of …