The three-dimensional structure of acetylcholinesterase from Torpedo californica electric
organ has been determined by x-ray analysis to 2.8 angstrom resolution. The form crystallized …

We have identified a new protein fold—the α/β hydrolase fold—that is common to several
hydrolytic enzymes of widely differing phylogenetic origin and catalytic function. The core of …

An easy-to-use, versatile and freely available graphic web server, FoldIndex© is described:
it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of …

Binding sites of Torpedo acetylcholinesterase (EC 3.1.1.7) for quaternary ligands were
investigated by x-ray crystallography and photoaffinity labeling. Crystal structures of complexes …

The application of bioinformatics methodologies to proteins inherently lacking 3D structure
has brought increased attention to these macromolecules. Here topics concerning these …

Background: Several cholinesterase inhibitors are either being utilized for symptomatic treatment
of Alzheimer's disease or are in advanced clinical trials. E2020, marketed as Aricept ® , …

By rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase terminates
neurotransmission at cholinergic synapses. Acetylcholinesterase is a very fast enzyme, …

Members of the serum paraoxonase (PON) family have been identified in mammals and other
vertebrates, and in invertebrates. PONs exhibit a wide range of physiologically important …

Based on the recently determined X‐ray structures of Torpedo californica acetylcholinesterase
and Geotrichum candidum lipase and on their three‐dimensional superposition, an …

The synaptic enzyme acetylcholinesterase (AChE) terminates transmission at cholinergic
synapses by rapidly hydrolysing acetylcholine. It is anchored within the synaptic cleft by a …