Molecular flexibility in ab initio drug docking to DNA: binding-site and binding-mode transitions in all-atom Monte Carlo simulations
R Rohs, I Bloch, H Sklenar, Z Shakked - Nucleic acids research, 2005 - academic.oup.com
The dynamics of biological processes depend on the structure and flexibility of the interacting
molecules. In particular, the conformational diversity of DNA allows for large deformations …
molecules. In particular, the conformational diversity of DNA allows for large deformations …
[HTML][HTML] Conserved interactions required for inhibition of the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
A Shitrit, D Zaidman, O Kalid, I Bloch, D Doron… - Scientific reports, 2020 - nature.com
The COVID-19 pandemic caused by the SARS-CoV-2 requires a fast development of antiviral
drugs. SARS-CoV-2 viral main protease (Mpro, also called 3C‐like protease, 3CLpro) is a …
drugs. SARS-CoV-2 viral main protease (Mpro, also called 3C‐like protease, 3CLpro) is a …
[HTML][HTML] Specificity in transmembrane helix-helix interactions mediated by aromatic residues
Aromatic residues have been previously shown to mediate the self-assembly of different soluble
proteins through π-π interactions (McGaughey, GB, Gagne, M., and Rappe, AK (1998) J. …
proteins through π-π interactions (McGaughey, GB, Gagne, M., and Rappe, AK (1998) J. …
[HTML][HTML] Oral subunit SARS-CoV-2 vaccine induces systemic neutralizing IgG, IgA and cellular immune responses and can boost neutralizing antibody responses …
…, K Emquies, H Israeli, H Haviv, I Rapoport, I Bloch… - Vaccine, 2022 - Elsevier
The rapid spread of the COVID-19 pandemic, with its devastating medical and economic
impacts, triggered an unprecedented race toward development of effective vaccines. The …
impacts, triggered an unprecedented race toward development of effective vaccines. The …
[HTML][HTML] Conversion of methionine biosynthesis in Escherichia coli from trans- to direct-sulfurylation enhances extracellular methionine levels
…, Y Hacham, H Haviv, I Stern, M Gabay, I Bloch… - Microbial Cell …, 2023 - Springer
Methionine is an essential amino acid in mammals and a precursor for vital metabolites
required for the survival of all organisms. Consequently, its inclusion is required in diverse …
required for the survival of all organisms. Consequently, its inclusion is required in diverse …
Newcastle disease virus: is an updated attenuated vaccine needed?
…, R Haddas, D Goldenberg, A Lublin, I Bloch… - Avian …, 2018 - Taylor & Francis
Newcastle disease virus (NDV) is a major cause of infectious mortality and morbidity in
poultry worldwide. It is an enveloped virus with two outer-membrane proteins—haemagglutinin-…
poultry worldwide. It is an enveloped virus with two outer-membrane proteins—haemagglutinin-…
T‐Cell inactivation and immunosuppressive activity induced by HIV gp41 via novel interacting motif
I Bloch, FJ Quintana, D Gerber, T Cohen… - The FASEB …, 2007 - Wiley Online Library
Fusion peptide (FP) of the HIV gp41 molecule inserts into the T cell membrane during virus‐cell
fusion. FP also blocks the TCR/CD3 interaction needed for antigen‐triggered T cell …
fusion. FP also blocks the TCR/CD3 interaction needed for antigen‐triggered T cell …
Intracellular protein–drug interactions probed by direct mass spectrometry of cell lysates
R Rogawski, A Rogel, I Bloch, M Gal… - Angewandte Chemie …, 2021 - Wiley Online Library
Understanding protein–ligand interactions in a cellular context is an important goal in
molecular biology and biochemistry, and particularly for drug development. Investigators must …
molecular biology and biochemistry, and particularly for drug development. Investigators must …
Constraints on axion-like dark matter from a SERF comagnetometer.
Ultralight axion-like particles are well-motivated relics that might compose the cosmological
dark matter and source anomalous time-dependent magnetic fields. We report on terrestrial …
dark matter and source anomalous time-dependent magnetic fields. We report on terrestrial …
D‐enantiomer peptide of the TCRa transmembrane domain inhibits T‐cell activation in vitro and in vivo
D Gerber, FJ Quintana, I Bloch, IR Cohen… - The FASEB …, 2005 - Wiley Online Library
T cell activation requires the cross‐talk between the CD3‐signaling complex and the T cell
receptor (TCR). A synthetic peptide coding for the TCRa transmembrane domain (CP) binds …
receptor (TCR). A synthetic peptide coding for the TCRa transmembrane domain (CP) binds …