In addition to activity, successful biological drugs must exhibit a series of suitable developability
properties, which depend on both protein sequence and buffer composition. In the …

Monoclonal antibodies (mAbs) are often formulated as high-protein-concentration solutions,
which in some cases can exhibit physical stability issues such as high viscosity and …

Prions consist of pathological aggregates of cellular prion protein and have the ability to
replicate, causing neurodegenerative diseases, a phenomenon mirrored in many other …

Circular dichroism spectroscopy has become a powerful tool to characterise proteins and other
biomolecules. For heterogeneous samples such as those present for interacting proteins, …

The clinical outcome of SARS-CoV-2 infections, which can range from asymptomatic to lethal,
is crucially shaped by the concentration of antiviral antibodies and by their affinity to their …

Oligomeric assemblies of the amyloid β peptide (Aβ) have been investigated for over two
decades as possible neurotoxic agents in Alzheimer’s disease. However, due to their …

Determination of individual rate constants for enzyme-catalyzed reactions is central to the
understanding of their mechanism of action and is commonly obtained by stopped-flow kinetic …

The clinical outcome of SARS-CoV-2 infections can range from asymptomatic to lethal, and
is thought to be crucially shaped by the quality of the immune response which includes …

… Marc Emmenegger; Elena De Cecco; David Lamparter; Raphael PB Jacquat; Julien Riou;
Dominik Menges; Tala Ballouz; Daniel Ebner; Matthias M Schneider; Itzel Condado Morales; …

Effective public health measures against SARS-CoV-2 require granular knowledge of
population-level immune responses. We developed a Tripartite Automated Blood Immunoassay (…