A simple trifluoromethoxylation method enables non‐directed functionalization of C−H
bonds on a range of substrates, providing access to aryl trifluoromethyl ethers. This light‐driven …

Difficulties associated with handling H 2 and CO in metal-catalyzed processes have led to the
development of chemical surrogates to these species. Despite many successful examples …

Recent advances in the palladium-catalyzed remote functionalization of carbonyl derivatives
are highlighted in this review. The structure of the article is based on the three strategies …

The incorporation of the gem‐difluoromethylene (CF 2 ) group into organic frameworks is
highly sought due to the influence of this unit on the physicochemical and pharmacological …

An enantioconvergent C(sp 3 )–C(sp 3 ) coupling between racemic allenylic electrophiles
and alkylzinc reagents has been developed. An Ir/(phosphoramidite,olefin) catalyst provides …

The mechanism of the palladium-catalyzed spirocyclization of acrylamides has been
investigated by density functional theory and experimental studies. The results support a …

HDAC6 plays a central role in the recruitment of protein aggregates for lysosomal degradation
and is a promising target for combination therapy with proteasome inhibitors in multiple …

Capitalizing on the late‐stage diversification of an essential 1,3‐diene intermediate, we
describe herein a 9‐step enantioselective total synthesis of (+)‐hyperforin and (+)‐pyrohyperforin…

Herein we report the first enantioselective total synthesis of 3,5‐dimethylorsellinic acid‐derived
meroterpenoids (−)‐berkeleyone A and its five congeners ((−)‐preaustinoids A, A1, B, B1…

Inhibitors of HDAC6 have attractive potential in numerous cancers. HDAC6 inhibitors to date
target the catalytic domains, but targeting the unique zinc-finger ubiquitin-binding domain (Zf…