User profiles for Ivan Laponogov

Dr Ivan Laponogov

Research Fellow
Verified email at imperial.ac.uk
Cited by 1170

Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases

I Laponogov, MK Sohi, DA Veselkov, XS Pan… - Nature structural & …, 2009 - nature.com
Type II topoisomerases alter DNA topology by forming a covalent DNA-cleavage complex that
allows DNA transport through a double-stranded DNA break. We present the structures of …

[HTML][HTML] Structural basis of gate-DNA breakage and resealing by type II topoisomerases

I Laponogov, XS Pan, DA Veselkov, KE McAuley… - PloS one, 2010 - journals.plos.org
Type II DNA topoisomerases are ubiquitous enzymes with essential functions in DNA
replication, recombination and transcription. They change DNA topology by forming a transient …

Auto-deconvolution and molecular networking of gas chromatography–mass spectrometry data

AA Aksenov, I Laponogov, Z Zhang, SLF Doran… - Nature …, 2021 - nature.com
We engineered a machine learning approach, MSHub, to enable auto-deconvolution of gas
chromatography–mass spectrometry (GC–MS) data. We then designed workflows to enable …

[HTML][HTML] HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods

…, R Mirnezami, J Youssef, M Bronstein, I Laponogov - Scientific reports, 2019 - nature.com
Recent data indicate that up-to 30–40% of cancers can be prevented by dietary and lifestyle
measures alone. Herein, we introduce a unique network-based machine learning platform …

Structure of an 'open'clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport

I Laponogov, DA Veselkov, IMT Crevel… - Nucleic acids …, 2013 - academic.oup.com
Type II topoisomerases regulate DNA supercoiling and chromosome segregation. They act
as ATP-operated clamps that capture a DNA duplex and pass it through a transient DNA …

ChemDistiller: an engine for metabolite annotation in mass spectrometry

I Laponogov, N Sadawi, D Galea, R Mirnezami… - …, 2018 - academic.oup.com
Motivation High-resolution mass spectrometry permits simultaneous detection of thousands
of different metabolites in biological samples; however, their automated annotation still …

Interceptor effect of C60 fullerene on the in vitro action of aromatic drug molecules

GB Skamrova, I Laponogov, AS Buchelnikov… - European Biophysics …, 2014 - Springer
C 60 fullerenes are spherical molecules composed purely of carbon atoms. They inspire a
particularly strong scientific interest because of their specific physico-chemical properties and …

[HTML][HTML] BASIS: High-performance bioinformatics platform for processing of large-scale mass spectrometry imaging data in chemically augmented histology

…, JPC Vissers, D Galea, A Mroz, I Laponogov… - Scientific reports, 2018 - nature.com
Mass Spectrometry Imaging (MSI) holds significant promise in augmenting digital
histopathologic analysis by generating highly robust big data about the metabolic, lipidomic and …

[HTML][HTML] Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae and comparison with a related Streptococcus …

DA Veselkov, I Laponogov, XS Pan… - … Section D: Structural …, 2016 - scripts.iucr.org
Klebsiella pneumoniae is a Gram-negative bacterium that is responsible for a range of
common infections, including pulmonary pneumonia, bloodstream infections and meningitis. …

Virus-induced volatile organic compounds are detectable in exhaled breath during pulmonary infection

…, AI Ritchie, DJ Wiseman, I Laponogov… - American Journal of …, 2021 - atsjournals.org
Rationale: Chronic obstructive pulmonary disease (COPD) is a condition punctuated by acute
exacerbations commonly triggered by viral and/or bacterial infection. Early identification of …