User profiles for Ivan Laponogov
Dr Ivan LaponogovResearch Fellow Verified email at imperial.ac.uk Cited by 1170 |
Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases
I Laponogov, MK Sohi, DA Veselkov, XS Pan… - Nature structural & …, 2009 - nature.com
Type II topoisomerases alter DNA topology by forming a covalent DNA-cleavage complex that
allows DNA transport through a double-stranded DNA break. We present the structures of …
allows DNA transport through a double-stranded DNA break. We present the structures of …
[HTML][HTML] Structural basis of gate-DNA breakage and resealing by type II topoisomerases
Type II DNA topoisomerases are ubiquitous enzymes with essential functions in DNA
replication, recombination and transcription. They change DNA topology by forming a transient …
replication, recombination and transcription. They change DNA topology by forming a transient …
Auto-deconvolution and molecular networking of gas chromatography–mass spectrometry data
We engineered a machine learning approach, MSHub, to enable auto-deconvolution of gas
chromatography–mass spectrometry (GC–MS) data. We then designed workflows to enable …
chromatography–mass spectrometry (GC–MS) data. We then designed workflows to enable …
[HTML][HTML] HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods
Recent data indicate that up-to 30–40% of cancers can be prevented by dietary and lifestyle
measures alone. Herein, we introduce a unique network-based machine learning platform …
measures alone. Herein, we introduce a unique network-based machine learning platform …
Structure of an 'open'clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport
I Laponogov, DA Veselkov, IMT Crevel… - Nucleic acids …, 2013 - academic.oup.com
Type II topoisomerases regulate DNA supercoiling and chromosome segregation. They act
as ATP-operated clamps that capture a DNA duplex and pass it through a transient DNA …
as ATP-operated clamps that capture a DNA duplex and pass it through a transient DNA …
ChemDistiller: an engine for metabolite annotation in mass spectrometry
Motivation High-resolution mass spectrometry permits simultaneous detection of thousands
of different metabolites in biological samples; however, their automated annotation still …
of different metabolites in biological samples; however, their automated annotation still …
Interceptor effect of C60 fullerene on the in vitro action of aromatic drug molecules
GB Skamrova, I Laponogov, AS Buchelnikov… - European Biophysics …, 2014 - Springer
C 60 fullerenes are spherical molecules composed purely of carbon atoms. They inspire a
particularly strong scientific interest because of their specific physico-chemical properties and …
particularly strong scientific interest because of their specific physico-chemical properties and …
[HTML][HTML] BASIS: High-performance bioinformatics platform for processing of large-scale mass spectrometry imaging data in chemically augmented histology
Mass Spectrometry Imaging (MSI) holds significant promise in augmenting digital
histopathologic analysis by generating highly robust big data about the metabolic, lipidomic and …
histopathologic analysis by generating highly robust big data about the metabolic, lipidomic and …
[HTML][HTML] Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae and comparison with a related Streptococcus …
DA Veselkov, I Laponogov, XS Pan… - … Section D: Structural …, 2016 - scripts.iucr.org
Klebsiella pneumoniae is a Gram-negative bacterium that is responsible for a range of
common infections, including pulmonary pneumonia, bloodstream infections and meningitis. …
common infections, including pulmonary pneumonia, bloodstream infections and meningitis. …
Virus-induced volatile organic compounds are detectable in exhaled breath during pulmonary infection
…, AI Ritchie, DJ Wiseman, I Laponogov… - American Journal of …, 2021 - atsjournals.org
Rationale: Chronic obstructive pulmonary disease (COPD) is a condition punctuated by acute
exacerbations commonly triggered by viral and/or bacterial infection. Early identification of …
exacerbations commonly triggered by viral and/or bacterial infection. Early identification of …