As the COVID-19 outbreak spreads, there is a growing need for a compilation of conserved
RNA genome regions in the SARS-CoV-2 virus along with their structural propensities to …

Drug discovery campaigns against COVID-19 are beginning to target the SARS-CoV-2 RNA
genome. The highly conserved frameshift stimulation element (FSE), required for balanced …

Earth’s life may have originated as self-replicating RNA, and it has been argued that RNA
viruses and viroid-like elements are remnants of such pre-cellular RNA world. RNA viruses are …

The discovery and design of biologically important RNA molecules is outpacing three-dimensional
structural characterization. Here, we demonstrate that cryo-electron microscopy can …

Vesicles formed from single-chain amphiphiles (SCAs) such as fatty acids probably played
an important role in the origin of life. A major criticism of the hypothesis that life arose in an …

The rapid spread of COVID-19 is motivating development of antivirals targeting conserved
SARS-CoV-2 molecular machinery. The SARS-CoV-2 genome includes conserved RNA …

The first RNA category of the Critical Assessment of Techniques for Structure Prediction
competition was only made possible because of the scientists who provided experimental …

Drug discovery campaigns against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
are beginning to target the viral RNA genome 1 , 2 . The frameshift stimulation …

Coronavirus genomes sequester their start codons within stem-loop 5 (SL5), a structured, 5′
genomic RNA element. In most alpha- and betacoronaviruses, the secondary structure of …

Today's genomics workflows typically require alignment to a reference sequence, which
limits discovery. We introduce a unifying paradigm, SPLASH (Statistically Primary aLignment …