Structural basis for the final steps of human 40S ribosome maturation

M Ameismeier, I Zemp, J van den Heuvel, M Thoms… - Nature, 2020 - nature.com
Eukaryotic ribosomes consist of a small 40S and a large 60S subunit that are assembled in
a highly coordinated manner. More than 200 factors ensure correct modification, processing …

Distinct cytoplasmic maturation steps of 40S ribosomal subunit precursors require hRio2

I Zemp, T Wild, MF O'Donohue, F Wandrey… - Journal of Cell …, 2009 - rupress.org
During their biogenesis, 40S ribosomal subunit precursors are exported from the nucleus to
the cytoplasm, where final maturation occurs. In this study, we show that the protein kinase …

[PDF][PDF] Genome-wide RNAi screening identifies protein modules required for 40S subunit synthesis in human cells

…, M Stebler, G Csucs, TU Mayer, N Zamboni, I Zemp… - Cell reports, 2015 - cell.com
Ribosome biogenesis is a highly complex process requiring many assisting factors. Studies
in yeast have yielded comprehensive knowledge of the cellular machinery involved in this …

USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit

…, C Ashiono, K Dörner, A Melnik, S Jonas, I Zemp… - Elife, 2020 - elifesciences.org
Establishment of translational competence represents a decisive cytoplasmic step in the
biogenesis of 40S ribosomal subunits. This involves final 18S rRNA processing and release of …

[HTML][HTML] Nuclear export and cytoplasmic maturation of ribosomal subunits

I Zemp, U Kutay - FEBS letters, 2007 - Elsevier
Based on the characterization of ribosome precursor particles and associated trans-acting
factors, a biogenesis pathway for the 40S and 60S subunits has emerged. After nuclear …

[HTML][HTML] A protein inventory of human ribosome biogenesis reveals an essential function of exportin 5 in 60S subunit export

…, E Wyler, B Widmann, L Badertscher, I Zemp… - PLoS …, 2010 - journals.plos.org
The assembly of ribosomal subunits in eukaryotes is a complex, multistep process so far mostly
studied in yeast. In S. cerevisiae, more than 200 factors including ribosomal proteins and …

The kinase activity of human Rio1 is required for final steps of cytoplasmic maturation of 40S subunits

…, E Wyler, J Pfannstiel, I Zemp… - Molecular biology of …, 2012 - Am Soc Cell Biol
RIO proteins form a conserved family of atypical protein kinases. Humans possess three
distinct RIO kinases—hRio1, hRio2, and hRio3, of which only hRio2 has been characterized …

Anguinomycins and derivatives: total syntheses, modeling, and biological evaluation of the inhibition of nucleocytoplasmic transport

…, O Eidam, S Güttinger, JY Wach, I Zemp… - Journal of the …, 2010 - ACS Publications
The preparation of the polyketide natural products anguinomycin C and D is reported based
on key steps such as Negishi stereoinversion cross coupling, Jacobsen Cr(III)-catalyzed …

Ribosome biogenesis factors—from names to functions

K Dörner, C Ruggeri, I Zemp, U Kutay - The EMBO journal, 2023 - embopress.org
The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified by …

A three-state model for the regulation of telomerase by TERRA and hnRNPA1

S Redon, I Zemp, J Lingner - Nucleic acids research, 2013 - academic.oup.com
Telomeres, the physical ends of eukaryotic chromosomes, are transcribed into telomeric
repeat-containing RNA (TERRA), a large non-coding RNA, which forms an integral part of …