Genomic analyses identify molecular subtypes of pancreatic cancer
…, MC Quinn, C Nourse, LC Murtaugh, I Harliwong… - Nature, 2016 - nature.com
Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently
mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/…
mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/…
Whole genomes redefine the mutational landscape of pancreatic cancer
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden.
We performed whole-genome sequencing and copy number variation (CNV) analysis of …
We performed whole-genome sequencing and copy number variation (CNV) analysis of …
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
…, MJ Cowley, BB Gardiner, S Song, I Harliwong… - Nature, 2012 - nature.com
Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed
exome sequencing and copy number analysis to define genomic aberrations in a …
exome sequencing and copy number analysis to define genomic aberrations in a …
Whole–genome characterization of chemoresistant ovarian cancer
…, RW Tothill, TP Holloway, T Semple, I Harliwong… - Nature, 2015 - nature.com
Patients with high-grade serous ovarian cancer (HGSC) have experienced little
improvement in overall survival, and standard treatment has not advanced beyond platinum-based …
improvement in overall survival, and standard treatment has not advanced beyond platinum-based …
Whole-genome landscape of pancreatic neuroendocrine tumours
The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to
more sensitive detection methods, and this increase is creating challenges for clinical …
more sensitive detection methods, and this increase is creating challenges for clinical …
[HTML][HTML] Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis
…, PJ Wilson, TJC Bruxner, AN Christ, I Harliwong… - Nature …, 2014 - nature.com
Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries.
A better understanding of EAC underpins efforts to improve early detection and treatment …
A better understanding of EAC underpins efforts to improve early detection and treatment …
Hypermutation in pancreatic cancer
Pancreatic cancer is molecularly diverse, with few effective therapies. Increased mutation
burden and defective DNA repair are associated with response to immune checkpoint …
burden and defective DNA repair are associated with response to immune checkpoint …
Comparison of long-read methods for sequencing and assembly of a plant genome
…, A Furtado, TJC Bruxner, W Tian, I Harliwong… - …, 2020 - academic.oup.com
Background Sequencing technologies have advanced to the point where it is possible to
generate high-accuracy, haplotype-resolved, chromosome-scale assemblies. Several long-…
generate high-accuracy, haplotype-resolved, chromosome-scale assemblies. Several long-…
[PDF][PDF] Ampullary cancers harbor ELF3 tumor suppressor gene mutations and exhibit frequent WNT dysregulation
The ampulla of Vater is a complex cellular environment from which adenocarcinomas arise
to form a group of histopathologically heterogenous tumors. To evaluate the molecular …
to form a group of histopathologically heterogenous tumors. To evaluate the molecular …
Integrated genomic and transcriptomic analysis of human brain metastases identifies alterations of potential clinical significance
…, TJC Bruxner, AN Christ, I Harliwong… - The Journal of …, 2015 - Wiley Online Library
Abstract Treatment options for patients with brain metastases ( BMs ) have limited efficacy
and the mortality rate is virtually 100%. Targeted therapy is critically under‐utilized, and our …
and the mortality rate is virtually 100%. Targeted therapy is critically under‐utilized, and our …