[PDF][PDF] Dynamic transcription of distinct classes of endogenous retroviral elements marks specific populations of early human embryonic cells
About half of the human genome consists of highly repetitive elements, most of which are
considered dispensable for human life. Here, we report that repetitive elements originating …
considered dispensable for human life. Here, we report that repetitive elements originating …
[HTML][HTML] Human pluripotent stem cell-derived organoids as models of liver disease
…, W Tng, KAU Gonzales, CP Tan, I Szczerbinska… - Gastroenterology, 2020 - Elsevier
Background & Aims There are few in vitro models for studying the 3-dimensional interactions
among different liver cell types during organogenesis or disease development. We aimed …
among different liver cell types during organogenesis or disease development. We aimed …
[PDF][PDF] ELABELA is an endogenous growth factor that sustains hESC self-renewal via the PI3K/AKT pathway
…, NB Ramakrishna, SC Chng, S Nama, I Szczerbinska… - Cell stem cell, 2015 - cell.com
ELABELA (ELA) is a peptide hormone required for heart development that signals via the
Apelin Receptor (APLNR, APJ). ELA is also abundantly secreted by human embryonic stem …
Apelin Receptor (APLNR, APJ). ELA is also abundantly secreted by human embryonic stem …
[HTML][HTML] Hepatocyte mARC1 promotes fatty liver disease
…, SR Nagarajan, J Norlin, CE Daly, I Szczerbinska… - JHEP Reports, 2023 - Elsevier
Background & Aims Non-alcoholic fatty liver disease (NAFLD) has a prevalence of ∼25%
worldwide, with significant public health consequences yet few effective treatments. Human …
worldwide, with significant public health consequences yet few effective treatments. Human …
[PDF][PDF] Krüppel-like factor 5 rewires NANOG regulatory network to activate human naive pluripotency specific LTR7Ys and promote naive pluripotency
Z Ai, X Xiang, Y Xiang, I Szczerbinska, Y Qian, X Xu… - Cell Reports, 2022 - cell.com
Endogenous retroviruses (ERVs) have been reported to participate in pre-implantation
development of mammalian embryos. In early human embryogenesis, different ERV sub-families …
development of mammalian embryos. In early human embryogenesis, different ERV sub-families …
[PDF][PDF] A chemically defined feeder-free system for the establishment and maintenance of the human naive pluripotent state
I Szczerbinska, KAU Gonzales, E Cukuroglu… - Stem Cell Reports, 2019 - cell.com
The distinct states of pluripotency in the pre- and post-implantation embryo can be captured
in vitro as naive and primed pluripotent stem cell cultures, respectively. The study and …
in vitro as naive and primed pluripotent stem cell cultures, respectively. The study and …
[HTML][HTML] Large-scale functional genomics screen to identify modulators of human β-cell insulin secretion
I Szczerbinska, A Tessitore, LK Hansson, A Agrawal… - Biomedicines, 2022 - mdpi.com
Type 2 diabetes (T2D) is a chronic metabolic disorder affecting almost half a billion people
worldwide. Impaired function of pancreatic β-cells is both a hallmark of T2D and an …
worldwide. Impaired function of pancreatic β-cells is both a hallmark of T2D and an …
Distinct SoxB1 networks are required for naïve and primed pluripotency
A Corsinotti, FCK Wong, T Tatar, I Szczerbinska… - Elife, 2017 - elifesciences.org
10.7554/eLife.27746.001 Deletion of Sox2 from mouse embryonic stem cells (ESCs) causes
trophectodermal differentiation. While this can be prevented by enforced expression of the …
trophectodermal differentiation. While this can be prevented by enforced expression of the …
A chemically well-defined, self-assembling 3D substrate for long-term culture of human pluripotent stem cells
Clinical applications of human pluripotent stem cells (PSCs) are limited by the lack of chemically
well-defined scaffolds for cell expansion, differentiation, and implantation. In this study, …
well-defined scaffolds for cell expansion, differentiation, and implantation. In this study, …
Distinct SoxB1 networks are required for naïve and primed pluripotency
C Andrea, FCK Wong, T Tülin, S Iwona, H Florian… - eLife, 2017 - search.proquest.com
Deletion of Sox2 from mouse embryonic stem cells (ESCs) causes trophectodermal
differentiation. While this can be prevented by enforced expression of the related SOXB1 proteins, …
differentiation. While this can be prevented by enforced expression of the related SOXB1 proteins, …