Uveitis is underappreciated as a sight-threatening cause of blindness. There are two broad
causative classes of uveitis: infectious and non-infectious. Non-infectious uveitis is …

The neuronal ceroid lipofuscinoses (NCLs), more commonly referred to as Batten disease,
are a group of inherited lysosomal storage disorders that present with neurodegeneration, …

Dendritic cells (DC) are the major antigen-presenting cells bridging innate and adaptive
immunity, a function they perform by converting quiescent DC to active, mature DC with the …

Exposure of bone‐marrow‐derived dendritic cells ( BMDC ) to high‐dose ultrapure
lipopolysaccharide for 24 hr ( LPS ‐primed BMDC ) enhances their potency in preventing inter‐…

Uveitis is a sight threatening intraocular inflammation accounting for approximately 10% of
blindness worldwide. On the basis of aetiology, disease can be classified as infectious or non-…

… after Cre expression and normal retinal vasculature at postnatal day (P)16 (ESM2). We sought
to … Liyanage have contributed equally to this work (as first authors); Izabela P. Klaska and …

We specify the clinical features of a spontaneous experimental autoimmune uveitis (EAU)
model, in which foreign hen-egg lysozyme (HEL) is expressed in the retina, controlled by the …

Restoration of immunological tolerance to self antigens has been a major drive in
understanding the mechanisms of, and developing new treatments for, autoimmune and …

Electrical gradients are present in many developing and regenerating tissues and around
tumours. Mimicking endogenous electric fields in vitro has profound effects on the behaviour of …

Since the plasticity and the potential for re-programming cells has become widely accepted,
there has been great interest in cell-based therapies. These are being applied to a range of …