Pleiotropy, the phenomenon of a single genetic variant influencing multiple traits, is likely
widespread in the human genome. If pleiotropy arises because the single nucleotide …

The National Osteoporosis Guideline Group (NOGG) has revised the UK guideline for the
assessment and management of osteoporosis and the prevention of fragility fractures in …

Purpose of Review Mendelian randomization (MR) is a strategy for evaluating causality in
observational epidemiological studies. MR exploits the fact that genotypes are not generally …

De novo assembly of RNA-seq data enables researchers to study transcriptomes without
the need for a genome sequence; this approach can be usefully applied, for instance, in …

10.7554/eLife.34408.001 Results from genome-wide association studies (GWAS) can be
used to infer causal relationships between phenotypes, using a strategy known as 2-sample …

… (⁠ α j ≠ 0 ⁠), then we have β j = β + α j γ j . The ratio estimate based on genetic variant …
We consider regression of the Γ ^ j coefficients on the γ ^ j coefficients where the intercept is …

Developments in genome‐wide association studies and the increasing availability of summary
genetic association data have made application of Mendelian randomization relatively …

An intergenerational program bringing together older adults with dementia and preschool
children in one-on-one interactions is described. Montessori activities, which have strong ties …

… their generous agreement for material presented by John Bowden at TEND 97, which is
included … -based, educational quality assurance system, in J Bowden and J Sachs (eds.), Quality …

Traditional measures of customer satisfaction have been criticized for failing to capture the
depth of customer responses to service performance. This study seeks to redirect satisfaction …