Background Genome-wide association studies (GWAS) in Parkinson's disease have increased
the scope of biological knowledge about the disease over the past decade. We aimed to …

Amyloid deposits, neurofibrillary tangles, and neuronal cell death in selectively vulnerable
brain regions are the chief hallmarks in Alzheimer's (AD) brains. Glycogen synthase kinase-3 (…

Background Frontotemporal dementia (FTD) is a complex disorder characterised by a broad
range of clinical manifestations, differential pathological signatures, and genetic variability. …

Background Alzheimer's disease and its complications are the leading cause of death in
adults with Down syndrome. Studies have assessed Alzheimer's disease in individuals with …

Mutations in three genes (PSEN1, PSEN2, and APP) have been identified in patients with
early-onset (<65years) Alzheimer's disease (AD). We performed a screening for mutations in …

… Jordi Clarimón contributed to drafting/revising the manuscript for content and acquisition of
data. Dr. María Carmona-Iragui contributed to drafting/revising the manuscript for content and …

Mutations in the glucocerebrosidase gene are associated with Parkinson's disease and Lewy
body dementia. However, whether these alterations have any effect on the clinical course …

… Author Contributions: Drs Clarimón and Kulisevsky had full access to all the data in the
study and take responsibility for the integrity of the data and the accuracy of the data analysis. …

Background Diagnosis of Alzheimer's disease in Down syndrome is challenging because of
the absence of validated diagnostic biomarkers. We investigated the diagnostic …

Introduction Large variability among Alzheimer's disease (AD) cases might impact genetic
discoveries and complicate dissection of underlying biological pathways. Methods Genome …