A central goal of genetics is to understand the links between genetic variation and disease.
Intuitively, one might expect disease-causing variants to cluster into key pathways that drive …

… Drs Brodeur and Pritchard served as cochairmen of the confJrence. Presented at the 6th …
Franklin IM, Pritchard J: Detection of bone marrow invasion by neuroblastoma is improved by …

… long mean free paths, we may treat the Lyα flux J α as being the same in both phases (although …
x i , x e , T K and J α . We begin by describing the evolution of the gas temperature T K , …

… The expected frequency of allele j is proportional to λ j , and the variance of this frequency
decreases as the sum of the λ j increases. We take λ 1 = λ 2 = ⋯ = λ Jl = 1.0, which gives a …

Genome-wide association studies have identified thousands of loci for common diseases,
but, for the majority of these, the mechanisms underlying disease susceptibility remain …

… In this section we summarize the models and methods used by Pritchard et al. (2000),
implemented in the program structure, available from http://www.stats .ox.ac.uk/pritch/home.html. …

Understanding the functional consequences of genetic variation, and how it affects complex
human disease and quantitative traits, remains a critical challenge for biomedicine. We …

We describe extensions to the method of Pritchard et al. for inferring population structure
from multilocus genotype data. Most importantly, we develop methods that allow for linkage …

… inline image , where j 1 …j B are the B different codominant alleles observed at that locus
and r is the recessive null allele (if applicable). Not all of the genotypes generated in this way …

… A scholar of religious thought and biblical archaeology, James Pritchard recruited the
foremost linguists, historians, and archaeologists to select and translate the texts. The goal, in his …