The intratumoral microenvironment, or stroma, is of major importance in the pathobiology of
pancreatic ductal adenocarcinoma (PDA), and specific conditions in the stroma may promote …

The malignant progression of pancreatic ductal adenocarcinoma (PDAC) is accompanied by
a profound desmoplasia, which forces proliferating tumor cells to metabolically adapt to this …

In pancreatic ductal adenocarcinoma (PDAC), signaling from stromal cells is implicated in
metastatic progression. Tumor-stroma cross-talk is often mediated through extracellular …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive stroma and pathogenic
modifications to the peripheral nervous system that elevate metastatic capacity. In this …

Objective Pancreatic cancer is associated with an abundant stromal reaction leading to
immune escape and tumour growth. This massive stroma drives the immune escape in the …

Neuronal nerve processes in the tumor microenvironment were highlighted recently.
However, the origin of intra-tumoral nerves remains poorly known, in part because of technical …

Background & Aims Cancer-associated fibroblasts (CAFs) from pancreatic adenocarcinoma
(PDA) present high protein synthesis rates. CAFs express the G-protein–coupled …

Pancreatic ductal adenocarcinoma (PDA) tumor cells are deprived of oxygen and nutrients
and therefore must adapt their metabolism to ensure proliferation. In some physiological …

Pancreatic ductal adenocarcinoma (PDA) is a fatal and insidious malignant disease for which
clinicians’ tools are restricted by the current limits in knowledge of how tumor and stromal …

Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies
with a mortality that is almost identical to incidence. Because early detected PDAC is …