In the embryo and in the adult, skeletal muscle growth is dependent on the proliferation and
the differentiation of muscle progenitors present within muscle masses. Despite the …

The early vertebrate skeletal muscle is a well-organized tissue in which the primitive muscle
fibres, the myocytes, are all parallel and aligned along the antero-posterior axis of the …

Myostatin, a TGF-β family member, is an important regulator of adult muscle size. While
extensively studied in vitro, the mechanisms by which this molecule mediates its effect in vivo are …

The regulation of cell adhesion in epithelia is a fundamental process governing morphogenesis
in embryos and a key step in the progression of invasive cancers. Here, we have …

The move of vertebrates to a terrestrial lifestyle required major adaptations in their
locomotory apparatus and reproductive organs. While the fin-to-limb transition has received …

The study of the morphogenetic cell movements underlying myotome formation in the chick
embryo has led to the emergence of highly controversial models. Here we report a real-time …

A Trp→Arg mutation at amino acid position 64 in the human β3‐adrenoceptor is reportedly
associated with morbid obesity; carriers suffer from increased gain in mass, early‐onset …

Background Quantitative imaging of epithelial tissues requires bioimage analysis tools that
are widely applicable and accurate. In the case of imaging 3D tissues, a common …

In vertebrates, the readily apparent left/right (L/R) anatomical asymmetries of the internal
organs can be traced to molecular events initiated at or near the time of gastrulation. However, …

Vertebrate limbs first emerge as small buds at specific locations along the trunk. Although a
fair amount is known about the molecular regulation of limb initiation and outgrowth, the …