Branching epithelial morphogenesis is closely linked to epithelial-to-mesenchymal transition
(EMT), a process important in normal development and cancer progression. The miR-200 …

In this study we examined loss of heterozygosity (LOH) on chromosome 13q12–13 in 50
tumors from BRCA2 carriers in five families showing strong evidence of linkage to BRCA2. In …

Germline mutations in the breast and ovarian cancer susceptibility gene BRCA1 are responsible
for the majority of cases involving hereditary breast and ovarian cancer. Whereas all …

A significant proportion of familial breast cancers cannot be explained by mutations in the
BRCA1 or BRCA2 genes. We applied a strategy to identify predisposition loci for breast cancer …

Almost every death in young patients with an advanced skin tumor is caused by melanoma.
Today, with the help of modern treatments, these patients survive longer or can even …

Understanding the complex events leading to formation of an epithelial-based organ such
as the breast requires a detailed insight into the crosstalk between epithelial and stromal …

The upper airways are lined with a pseudostratified bronchial epithelium that forms a barrier
against unwanted substances in breathing air. The transcription factor p63, which is …

The majority of breast cancer in high risk families is believed to result from a mutation in
either of two genes named BRCA1 and BRCA2. A germline defect in either gene is usually …

Epithelial-to-mesenchymal transition (EMT) and its reversed process mesenchymal-to-epithelial
transition (MET) play a critical role in epithelial plasticity during development and cancer …

Cloning of a breast cancer-predisposing gene (BRCA2) on chromosome 13Q12-14 has been
reported recently. We analyzed seven large Icelandic breast cancer families with markers …