User profiles for József Kardos

József Kardos

Eötvös Loránd University
Verified email at elte.hu
Cited by 6679

Accurate secondary structure prediction and fold recognition for circular dichroism spectroscopy

…, Y Goto, M Réfrégiers, J Kardos - Proceedings of the …, 2015 - National Acad Sciences
Circular dichroism (CD) spectroscopy is a widely used technique for the study of protein
structure. Numerous algorithms have been developed for the estimation of the secondary …

BeStSel: a web server for accurate protein secondary structure prediction and fold recognition from the circular dichroism spectra

…, YH Lee, Y Goto, M Réfrégiers, J Kardos - Nucleic acids …, 2018 - academic.oup.com
Circular dichroism (CD) spectroscopy is a widely used method to study the protein secondary
structure. However, for decades, the general opinion was that the correct estimation of β-…

Adjustment of conformational flexibility is a key event in the thermal adaptation of proteins

PE ZAvodszky, J Kardos, Á Svingor… - Proceedings of the …, 1998 - National Acad Sciences
3-Isopropylmalate dehydrogenase (IPMDH, EC 1.1.1.85) from the thermophilic bacterium
Thermus thermophilus HB8 is homologous to IPMDH from the mesophilic Escherichia coli, but …

BeStSel: webserver for secondary structure and fold prediction for protein CD spectroscopy

…, M Réfrégiers, Y Goto, Á Tantos, J Kardos - Nucleic Acids …, 2022 - academic.oup.com
Circular dichroism (CD) spectroscopy is widely used to characterize the secondary structure
composition of proteins. To derive accurate and detailed structural information from the CD …

Low Concentrations of Sodium Dodecyl Sulfate Induce the Extension of β2-Microglobulin-Related Amyloid Fibrils at a Neutral pH

…, K Hasegawa, I Yamaguchi, S Tsutsumi, J Kardos… - Biochemistry, 2004 - ACS Publications
In β 2 -microglobulin-related (Aβ2M) amyloidosis, partial unfolding of β 2 -microglobulin (β2-m)
is believed to be prerequisite to its assembly into Aβ2M amyloid fibrils in vivo. Although …

Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning

…, G Juhász, KA Kékesi, J Kardos - Proceedings of the …, 2018 - National Acad Sciences
C1q, a member of the immune complement cascade, is implicated in the selective pruning of
synapses by microglial phagocytosis. C1q-mediated synapse elimination has been shown …

[HTML][HTML] Direct measurement of the thermodynamic parameters of amyloid formation by isothermal titration calorimetry

J Kardos, K Yamamoto, K Hasegawa, H Naiki… - Journal of Biological …, 2004 - ASBMB
Amyloid fibril deposition is associated with over 20 degenerative diseases, including
Alzheimer's, Parkinson's, and prion diseases. Although research over the last few years has …

[HTML][HTML] BeStSel: from secondary structure analysis to protein fold prediction by circular dichroism spectroscopy

A Micsonai, É Bulyáki, J Kardos - Structural Genomics: General …, 2021 - Springer
Far-UV circular dichroism (CD) spectroscopy is a classical method for the study of the
secondary structure of polypeptides in solution. It has been the general view that the α-helix …

Cold Denaturation of α‐Synuclein Amyloid Fibrils

T Ikenoue, YH Lee, J Kardos, M Saiki… - Angewandte Chemie …, 2014 - Wiley Online Library
Although amyloid fibrils are associated with numerous pathologies, their conformational
stability remains largely unclear. Herein, we probe the thermal stability of various amyloid fibrils. …

Heat of supersaturation-limited amyloid burst directly monitored by isothermal titration calorimetry

T Ikenoue, YH Lee, J Kardos, H Yagi… - Proceedings of the …, 2014 - National Acad Sciences
Amyloid fibrils form in supersaturated solutions via a nucleation and growth mechanism.
Although the structural features of amyloid fibrils have become increasingly clearer, knowledge …