The organization of a cell emerges from the interactions in protein networks. The interactome
is critically dependent on the strengths of interactions and the cellular abundances of the …

We introduce real-time deformability cytometry (RT-DC) for continuous cell mechanical
characterization of large populations (>100,000 cells) with analysis rates greater than 100 cells/s. …

Following DNA damage caused by exogenous sources, such as ionizing radiation, the
tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21. …

The anaphase-promoting complex (APC/C), a ubiquitin ligase, is the target of the spindle-assembly
checkpoint (SAC), and it ubiquitylates protein substrates whose degradation …

Nuclear pore complexes (NPCs) are large proteinaceous channels embedded in the nuclear
envelope (NE), through which exchange of molecules between the nucleus and cytosol …

Reactive oxygen species (ROS) at the right concentration promote cell proliferation in cell
culture, stem cells, and model organisms. However, the mystery of how ROS signaling is …

The anaphase-promoting complex or cyclosome (APC/C) is the ubiquitin ligase that regulates
mitosis by targeting specific proteins for degradation at specific times under the control of …

Commitment to mitosis must be tightly coordinated with DNA replication to preserve
genome integrity. While we have previously established that the timely activation of CyclinB1-Cdk1 …

Faithful chromosome segregation during mitosis depends on the spindle assembly
checkpoint (SAC), which monitors kinetochore attachment to the mitotic spindle. Unattached …

Cell cycle kinetics are crucial to cell fate decisions. Although live imaging has provided
extensive insights into this relationship at the single-cell level, the limited number of fluorescent …