User profiles for Jørgen Kjems
Jørgen KjemsInterdisciplinary Nanoscience Centre (iNANO) Department of Molecular Biology and … Verified email at mb.au.dk Cited by 43968 |
The biogenesis, biology and characterization of circular RNAs
Circular RNAs (circRNAs) are covalently closed, endogenous biomolecules in eukaryotes
with tissue-specific and cell-specific expression patterns, whose biogenesis is regulated by …
with tissue-specific and cell-specific expression patterns, whose biogenesis is regulated by …
Single-molecule chemical reactions on DNA origami
DNA nanotechnology 1 , 2 and particularly DNA origami 3 , in which long, single-stranded
DNA molecules are folded into predetermined shapes, can be used to form complex self-…
DNA molecules are folded into predetermined shapes, can be used to form complex self-…
A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity
The use of chemically synthesized short interfering RNAs (siRNAs) is currently the method
of choice to manipulate gene expression in mammalian cell culture, yet improvements of …
of choice to manipulate gene expression in mammalian cell culture, yet improvements of …
Coordinated epigenetic repression of the miR‐200 family and miR‐205 in invasive bladder cancer
MicroRNAs (miRNA) are small noncoding RNAs commonly deregulated in cancer. The miR‐200
family (miR‐200a, ‐200b, ‐200c, ‐141 and ‐429) and miR‐205 are frequently silenced …
family (miR‐200a, ‐200b, ‐200c, ‐141 and ‐429) and miR‐205 are frequently silenced …
Natural RNA circles function as efficient microRNA sponges
…, JB Bramsen, B Finsen, CK Damgaard, J Kjems - Nature, 2013 - nature.com
MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression that
act by direct base pairing to target sites within untranslated regions of messenger RNAs 1 . …
act by direct base pairing to target sites within untranslated regions of messenger RNAs 1 . …
The emerging roles of circRNAs in cancer and oncology
Over the past decade, circular RNAs (circRNAs) have emerged as a large class of primarily
non-coding RNA molecules, many of which have key roles in cancer development and …
non-coding RNA molecules, many of which have key roles in cancer development and …
Self-assembly of a nanoscale DNA box with a controllable lid
The unique structural motifs and self-recognition properties of DNA can be exploited to generate
self-assembling DNA nanostructures of specific shapes using a ‘bottom-up’ approach 1 …
self-assembling DNA nanostructures of specific shapes using a ‘bottom-up’ approach 1 …
[HTML][HTML] Circular RNAs in cancer: opportunities and challenges in the field
Circular RNA (circRNA) is a novel member of the noncoding cancer genome with distinct
properties and diverse cellular functions, which is being explored at a steadily increasing pace. …
properties and diverse cellular functions, which is being explored at a steadily increasing pace. …
miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA
MicroRNAs (miRNAs) are ∼22 nt non‐coding RNAs that typically bind to the 3′ UTR of target
mRNAs in the cytoplasm, resulting in mRNA destabilization and translational repression. …
mRNAs in the cytoplasm, resulting in mRNA destabilization and translational repression. …
Circular RNA and miR-7 in cancer
MicroRNAs (miRNA) play important roles in fine-tuning gene expression and are often
deregulated in cancer. The identification of competing endogenous RNA and circular RNA (…
deregulated in cancer. The identification of competing endogenous RNA and circular RNA (…