User profiles for Jørgen Kjems

Jørgen Kjems

Interdisciplinary Nanoscience Centre (iNANO) Department of Molecular Biology and …
Verified email at mb.au.dk
Cited by 43968

The biogenesis, biology and characterization of circular RNAs

…, KK Ebbesen, TB Hansen, J Kjems - Nature reviews …, 2019 - nature.com
Circular RNAs (circRNAs) are covalently closed, endogenous biomolecules in eukaryotes
with tissue-specific and cell-specific expression patterns, whose biogenesis is regulated by …

Single-molecule chemical reactions on DNA origami

…, R Subramani, W Mamdouh, J Kjems… - Nature …, 2010 - nature.com
DNA nanotechnology 1 , 2 and particularly DNA origami 3 , in which long, single-stranded
DNA molecules are folded into predetermined shapes, can be used to form complex self-…

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

…, P Herdewijn, J Wengel, J Kjems - Nucleic acids …, 2009 - academic.oup.com
The use of chemically synthesized short interfering RNAs (siRNAs) is currently the method
of choice to manipulate gene expression in mammalian cell culture, yet improvements of …

Coordinated epigenetic repression of the miR‐200 family and miR‐205 in invasive bladder cancer

…, M Borre, ME Peter, TF Ørntoft, J Kjems… - … journal of cancer, 2011 - Wiley Online Library
MicroRNAs (miRNA) are small noncoding RNAs commonly deregulated in cancer. The miR‐200
family (miR‐200a, ‐200b, ‐200c, ‐141 and ‐429) and miR‐205 are frequently silenced …

Natural RNA circles function as efficient microRNA sponges

…, JB Bramsen, B Finsen, CK Damgaard, J Kjems - Nature, 2013 - nature.com
MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression that
act by direct base pairing to target sites within untranslated regions of messenger RNAs 1 . …

The emerging roles of circRNAs in cancer and oncology

…, T Jakobsen, H Hager, J Kjems - Nature reviews Clinical …, 2022 - nature.com
Over the past decade, circular RNAs (circRNAs) have emerged as a large class of primarily
non-coding RNA molecules, many of which have key roles in cancer development and …

Self-assembly of a nanoscale DNA box with a controllable lid

…, V Birkedal, F Besenbacher, KV Gothelf, J Kjems - Nature, 2009 - nature.com
The unique structural motifs and self-recognition properties of DNA can be exploited to generate
self-assembling DNA nanostructures of specific shapes using a ‘bottom-up’ approach 1 …

[HTML][HTML] Circular RNAs in cancer: opportunities and challenges in the field

LS Kristensen, TB Hansen, MT Venø, J Kjems - Oncogene, 2018 - nature.com
Circular RNA (circRNA) is a novel member of the noncoding cancer genome with distinct
properties and diverse cellular functions, which is being explored at a steadily increasing pace. …

miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA

…, SB Villadsen, AL Statham, SJ Clark, J Kjems - The EMBO …, 2011 - embopress.org
MicroRNAs (miRNAs) are ∼22 nt non‐coding RNAs that typically bind to the 3′ UTR of target
mRNAs in the cytoplasm, resulting in mRNA destabilization and translational repression. …

Circular RNA and miR-7 in cancer

TB Hansen, J Kjems, CK Damgaard - Cancer research, 2013 - AACR
MicroRNAs (miRNA) play important roles in fine-tuning gene expression and are often
deregulated in cancer. The identification of competing endogenous RNA and circular RNA (…