Serum microRNAs as powerful cancer biomarkers

J Wittmann, HM Jäck - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2010 - Elsevier
MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression
at the posttranscriptional level by either degrading or blocking translation of messenger RNA …

hUPF2 silencing identifies physiologic substrates of mammalian nonsense-mediated mRNA decay

J Wittmann, EM Hol, HM Jäck - Molecular and cellular biology, 2006 - Taylor & Francis
Nonsense-mediated mRNA decay (NMD) is a conserved eukaryotic surveillance pathway
that selectively degrades aberrant mRNAs with premature termination codons (PTCs). …

Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus

S Kiechl, J Wittmann, A Giaccari, M Knoflach, P Willeit… - Nature medicine, 2013 - nature.com
Hepatic insulin resistance is a driving force in the pathogenesis of type 2 diabetes mellitus (T2DM)
and is tightly coupled with excessive storage of fat and the ensuing inflammation …

miR‐148a promotes plasma cell differentiation and targets the germinal center transcription factors Mitf and Bach2

…, E Roth, A Radbruch, J Wittmann… - European journal of …, 2015 - Wiley Online Library
B cells undergo affinity maturation and class switch recombination of their immunoglobulin
receptors during a germinal center (GC) reaction, before they differentiate into long‐lived …

miR‐148a is upregulated by Twist1 and T‐bet and promotes Th1‐cell survival by regulating the proapoptotic gene Bim

…, M Löhning, A Scheffold, J Wittmann… - European journal of …, 2015 - Wiley Online Library
Repeatedly activated T helper 1 (Th1) cells present during chronic inflammation can efficiently
adapt to the inflammatory milieu, for example, by expressing the transcription factor Twist1…

The negative regulator Opi1 of phospholipid biosynthesis in yeast contacts the pleiotropic repressor Sin3 and the transcriptional activator Ino2

C Wagner, M Dietz, J Wittmann, A Albrecht… - Molecular …, 2001 - Wiley Online Library
Structural genes of phospholipid biosynthesis in the yeast Saccharomyces cerevisiae are
transcriptionally co‐regulated by ICRE (inositol/choline‐responsive element) promoter motifs. …

The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6/EIF3E and UPF1

…, JM Terme, M Duc Dodon, J Wittmann… - Journal of …, 2012 - Am Soc Microbiol
In this report, we analyzed whether the degradation of mRNAs by the nonsense-mediated
mRNA decay (NMD) pathway was affected in human T-lymphotropic virus type 1 (HTLV-1)-…

Science fact vs science fiction: a ChatGPT immunological review experiment gone awry

J Wittmann - Immunology Letters, 2023 - Elsevier
Artificial intelligence (AI) has made great progress in recent years. The latest chatbot to
make a splash is ChatGPT. To see if this type of AI could also be helpful in creating an …

miR‐9 enhances IL‐2 production in activated human CD4+ T cells by repressing Blimp‐1

S Thiele, J Wittmann, HM Jäck… - European journal of …, 2012 - Wiley Online Library
The fast production of effector cytokines, such as IL‐2, is essential for the autocrine function
in the rapid activation of naive CD4 + T cells. Here, we show that the microRNA (miRNA) …

microRNAs in rheumatoid arthritis: midget RNAs with a giant impact

J Wittmann, HM Jäck - Annals of the rheumatic diseases, 2011 - ard.bmj.com
MicroRNAs (miRNAs) are tiny, non-coding molecules that primarily modulate gene
expression at the post-transcriptional level by predominantly hybridising to complementary …