Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic
architecture or its genetic relationship with other disorders. To discover loci associated …

Excessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with
substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness …

Background: The authors investigated correlates of depression in a general population
sample of adolescents (15–19 years) and young adults (20–24 years). Methods: As part of the …

The association between telomere length (TL) dynamics on cognitive performance over the
life-course is not well understood. This study meta-analyses observational and causal …

Background Fibromyalgia (FM) is a pain syndrome, the mechanisms and predictors of which
are still unclear. We have earlier validated a set of FM-symptom questions for detecting …

… Rose and Jaakko Kaprio made substantial contributions to the study's conception and
design. Minna Ståhl, Ashraf El-Metwally and Jaakko Kaprio analysed and interpreted the data. …

A deletion variant of the α 2B -adrenergic receptor (α 2B -AR) has been associated with an
increased risk of acute cardiac events in middle-aged men. Our aim was to determine the …

Background The heritability of traits such as body mass index (BMI), a measure of obesity, is
generally estimated using family and twin studies, and increasingly by molecular genetic …

The main health risks of modern oral contraceptives (OCs) are associated with simultaneous
smoking. According to current medical guidelines in Finland, OCs should not be prescribed …

… Kaprio JA, Koskenvuo K, Sarna S. Prog. Clin. …