Success of an immunotherapy for cancer often depends on the critical balance of T helper 1
(Th1) and T helper 2 (Th2) responses driven by antigen presenting cells, specifically …

… Using synthetic pathogen-like particles (PLPs), Leleux et al. have discovered that the
quality and quantity of Toll-like receptor 9 (TLR9) signaling by CpG in mouse dendritic cells (mDCs…

Systemic interleukin-12 (IL12) anti-tumor therapy is highly potent but has had limited utility
in the clinic due to severe toxicity. Here, we present two IL12-expressing vector platforms, …

Despite significant efforts, development of clinically relevant prophylactic and therapeutic
cancer vaccines has proven challenging. Cancer-associated antigens, which are often self-…

Therapeutic cancer vaccines must induce high levels of tumor-specific cytotoxic CD8 T cells
to be effective. We show here that tumor-antigen specific effector and memory T cell …

Microbial pathogens range in size, shape, as well as biochemical and molecular properties.
This has led to the evolution of a variety of pathogen recognition receptors (PRRs) in …

Electronic devices that interface with living tissue have become a necessity in clinics to improve
diagnosis and treatments. Devices such as cardiac pacemakers and cochlear implants …

In vivo electrophysiological recordings of neuronal circuits are necessary for diagnostic
purposes and for brain-machine interfaces. Organic electronic devices constitute a promising …

A key difference between organic electronic materials and inorganic ones such as silicon
lies in the ability of the former to transport ions with significant mobilities at room temperature. …

As lab-on-chip platforms for biomedical applications become more sophisticated by
increasing the number of fluidic, electronic, and/or mechanical components, space and design …