… With this goal in mind, senior leadership began to discuss the concept of a genomics core
in the early 2000s 9 and led to the launch of the MyCode® biorepository in 2007. From its …

Background Loss-of-function variants in the angiopoietin-like 3 gene (ANGPTL3) have been
associated with decreased plasma levels of triglycerides, low-density lipoprotein (LDL) …

INTRODUCTION Large-scale genetic studies of integrated health care populations, with
phenotypic data captured natively in the documentation of clinical care, have the potential to …

Background Higher-than-normal levels of circulating triglycerides are a risk factor for ischemic
cardiovascular disease. Activation of lipoprotein lipase, an enzyme that is inhibited by …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters human host cells
via angiotensin-converting enzyme 2 (ACE2) and causes coronavirus disease 2019 (COVID-…

INTRODUCTION Familial hypercholesterolemia (FH) is a public health genomics priority but
remains underdiagnosed and undertreated despite widespread cholesterol screening. This …

The UK Biobank is a prospective study of 502,543 individuals, combining extensive phenotypic
and genotypic data with streamlined access for researchers around the world 1 . Here …

The electrocardiogram (ECG) is a widely used medical test, consisting of voltage versus
time traces collected from surface recordings over the heart 1 . Here we hypothesized that a …

Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to
disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals with …

OBJECTIVE: There have been few naturalistic follow-up studies of dysthymic disorder. This
study describes the 5-year course and outcome of dysthymic disorder.METHOD: The authors …