Widely varied chemicals—including certain herbicides, plasticizers, drugs, and natural
products—induce peroxisome proliferation in rodent liver and other tissues. This phenomenon is …

Peroxisome proliferators (PPs) are a large class of structurally dissimilar chemicals that
have diverse effects in rodents and humans. Most, if not all, of the diverse effects of PPs are …

Several therapeutic agents and industrial chemicals induce liver tumors in rodents through
the activation of the peroxisome proliferator-activated receptor alpha (PPARα). The cellular …

Over the last decade, the introduction of microarray technology has had a profound impact
on gene expression research. The publication of studies with dissimilar or altogether …

The rat, mouse and human estrogen receptor (ER) exists as two subtypes, ERα and ERβ,
which differ in the C-terminal ligand-binding domain and in the N-terminal transactivation …

Ablation of peroxisome proliferator activated receptor (PPAR) α, a lipid-activated transcription
factor that regulates expression of β-oxidative genes, results in profound metabolic …

Toxicogenomic analysis of five environmental chemicals was performed to investigate the
ability of genomics to predict toxicity, categorize chemicals, and elucidate mechanisms of …

Phthalate esters belong to a large class of compounds known as peroxisome proliferators (PP).
PP include chemicals that activate different subtypes of the peroxisome proliferator-…

Persistent presence of perfluoroalkyl acids (PFAAs) in the environment is due to their
extensive use in industrial and consumer products, and their slow decay. Biochemical tests in …

A number of perfluorinated alkyl acids including perfluorooctanoic acid (PFOA) elicit effects
similar to peroxisome proliferator chemicals (PPC) in mouse and rat liver. There is strong …