User profiles for J. D. Buenrostro
Jason BuenrostroHarvard University Verified email at harvard.edu Cited by 22991 |
Single-cell and single-molecule epigenomics to uncover genome regulation at unprecedented resolution
Recent advances in single-cell and single-molecule epigenomic technologies now enable
the study of genome regulation and dynamics at unprecedented resolution. In this Perspective…
the study of genome regulation and dynamics at unprecedented resolution. In this Perspective…
[PDF][PDF] Advances in chromatin and chromosome research: perspectives from multiple fields
Nucleosomes package genomic DNA into chromatin. By regulating DNA access for transcription,
replication, DNA repair, and epigenetic modification, chromatin forms the nexus of most …
replication, DNA repair, and epigenetic modification, chromatin forms the nexus of most …
ATAC‐seq: a method for assaying chromatin accessibility genome‐wide
JD Buenrostro, B Wu, HY Chang… - Current protocols in …, 2015 - Wiley Online Library
… A complete list of primers is available in Buenrostro et al. (2013). Care should be taken to
ensure that samples are barcoded appropriately for subsequent pooling and sequencing. …
ensure that samples are barcoded appropriately for subsequent pooling and sequencing. …
[HTML][HTML] Chromatin potential identified by shared single-cell profiling of RNA and chromatin
Cell differentiation and function are regulated across multiple layers of gene regulation,
including modulation of gene expression by changes in chromatin accessibility. However, …
including modulation of gene expression by changes in chromatin accessibility. However, …
Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
We describe an assay for transposase-accessible chromatin using sequencing (ATAC-seq),
based on direct in vitro transposition of sequencing adaptors into native chromatin, as a …
based on direct in vitro transposition of sequencing adaptors into native chromatin, as a …
Single-cell chromatin accessibility reveals principles of regulatory variation
JD Buenrostro, B Wu, UM Litzenburger, D Ruff… - Nature, 2015 - nature.com
Cell-to-cell variation is a universal feature of life that affects a wide range of biological
phenomena, from developmental plasticity 1 , 2 to tumour heterogeneity 3 . Although recent …
phenomena, from developmental plasticity 1 , 2 to tumour heterogeneity 3 . Although recent …
Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution
We define the chromatin accessibility and transcriptional landscapes in 13 human primary
blood cell types that span the hematopoietic hierarchy. Exploiting the finding that the …
blood cell types that span the hematopoietic hierarchy. Exploiting the finding that the …
chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data
… Lareau for valuable suggestions for improvements on the package as well as members
of the Greenleaf and Buenrostro labs for useful discussions. … Jason D Buenrostro …
of the Greenleaf and Buenrostro labs for useful discussions. … Jason D Buenrostro …
Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types
…, Brainstorm Consortium, JRB Perry, JD Buenrostro… - Nature …, 2018 - nature.com
We introduce an approach to identify disease-relevant tissues and cell types by analyzing
gene expression data together with genome-wide association study (GWAS) summary …
gene expression data together with genome-wide association study (GWAS) summary …
[PDF][PDF] Integrated single-cell analysis maps the continuous regulatory landscape of human hematopoietic differentiation
… to explore chromatin accessibility differences in single-cell profiles (Buenrostro et al., 2015b).
Here, we … We thank members of Greenleaf, Chang, Majeti, and Buenrostro labs for valuable …
Here, we … We thank members of Greenleaf, Chang, Majeti, and Buenrostro labs for valuable …