User profiles for J. D. Steimle
 | Jeffrey D SteimleBaylor College of Medicine Verified email at bcm.edu Cited by 637 |
TBX5: a key regulator of heart development
JD Steimle, IP Moskowitz - Current topics in developmental biology, 2017 - Elsevier
TBX5 is a member of the T-box transcription factor family and is primarily known for its role
in cardiac and forelimb development. Human patients with dominant mutations in TBX5 are …
in cardiac and forelimb development. Human patients with dominant mutations in TBX5 are …
[HTML][HTML] De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects
…, S Reddy, D Bernstein, T Burns, JD Steimle… - PLoS …, 2016 - journals.plos.org
Congenital heart disease (CHD) has a complex genetic etiology, and recent studies suggest
that high penetrance de novo mutations may account for only a small fraction of disease. In …
that high penetrance de novo mutations may account for only a small fraction of disease. In …
[HTML][HTML] Foxf Genes Integrate Tbx5 and Hedgehog Pathways in the Second Heart Field for Cardiac Septation
…, JD Bosman, X Ren, JD Steimle… - PLoS …, 2014 - journals.plos.org
The Second Heart Field (SHF) has been implicated in several forms of congenital heart
disease (CHD), including atrioventricular septal defects (AVSDs). Identifying the SHF gene …
disease (CHD), including atrioventricular septal defects (AVSDs). Identifying the SHF gene …
[PDF][PDF] The cardiac TBX5 interactome reveals a chromatin remodeling network essential for cardiac septation
Human mutations in the cardiac transcription factor gene TBX5 cause congenital heart
disease (CHD), although the underlying mechanism is unknown. We report characterization of …
disease (CHD), although the underlying mechanism is unknown. We report characterization of …
Evolutionarily conserved Tbx5–Wnt2/2b pathway orchestrates cardiopulmonary development
JD Steimle, SA Rankin, CE Slagle… - Proceedings of the …, 2018 - National Acad Sciences
Codevelopment of the lungs and heart underlies key evolutionary innovations in the transition
to terrestrial life. Cardiac specializations that support pulmonary circulation, including the …
to terrestrial life. Cardiac specializations that support pulmonary circulation, including the …
Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms
O Burnicka-Turek, JD Steimle, W Huang… - Human molecular …, 2016 - academic.oup.com
Atrioventricular septal defects (AVSDs) are a common severe form of congenital heart
disease (CHD). In this study we identified deleterious non-synonymous mutations in two cilia …
disease (CHD). In this study we identified deleterious non-synonymous mutations in two cilia …
Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development
SA Rankin, JD Steimle, XH Yang, AB Rydeen… - Elife, 2021 - elifesciences.org
… are essential for both heart and lung development (Steimle et al., 2018). Endodermal Hh
signals … - dissected cardiopulmonary progenitor (CPP) tissue based on bulk RNA- seq (Steimle …
signals … - dissected cardiopulmonary progenitor (CPP) tissue based on bulk RNA- seq (Steimle …
Transcriptional dysregulation underlies both monogenic arrhythmia syndrome and common modifiers of cardiac repolarization
… Drs Bersell and Parikh, and JD Steimle are supported by the National Heart, Lung, and …
Hale AT CB, York JD. Metabolic labeling of inositol phosphates and phosphatidylinositols in …
Hale AT CB, York JD. Metabolic labeling of inositol phosphates and phosphatidylinositols in …
Transcriptional patterning of the ventricular cardiac conduction system
O Burnicka-Turek, MT Broman, JD Steimle… - Circulation …, 2020 - Am Heart Assoc
Rationale: The heartbeat is organized by the cardiac conduction system (CCS), a specialized
network of cardiomyocytes. Patterning of the CCS into atrial node versus ventricular …
network of cardiomyocytes. Patterning of the CCS into atrial node versus ventricular …
[HTML][HTML] Decoding the PITX2-controlled genetic network in atrial fibrillation
JD Steimle, FJG Canozo, M Park, ZA Kadow… - Jci Insight, 2022 - ncbi.nlm.nih.gov
Atrial fibrillation (AF), the most common sustained cardiac arrhythmia and a major risk factor
for stroke, often arises through ectopic electrical impulses derived from the pulmonary veins (…
for stroke, often arises through ectopic electrical impulses derived from the pulmonary veins (…