User profiles for J. E. Crowe

James Crowe

Vanderbilt University Medical Center
Verified email at vanderbilt.edu
Cited by 36045

[HTML][HTML] An infectious SARS-CoV-2 B. 1.1. 529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies

…, JM Errico, PJ Halfmann, SJ Zost, JE Crowe Jr… - Nature medicine, 2022 - nature.com
… The Crowe laboratory has received sponsored research agreements from Takeda Vaccines,
AstraZeneca and IDBiologics. Vanderbilt University has applied for patents related to two …

[HTML][HTML] Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies

…, P Deepak, D Pinto, DH Fremont, JE Crowe Jr… - Nature medicine, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the global
COVID-19 pandemic. Rapidly spreading SARS-CoV-2 variants may jeopardize newly …

[HTML][HTML] Potently neutralizing and protective human antibodies against SARS-CoV-2

…, MS Diamond, RH Carnahan, JE Crowe Jr - Nature, 2020 - nature.com
The ongoing pandemic of coronavirus disease 2019 (COVID-19), which is caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major threat to global health …

[PDF][PDF] Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition

…, Z Liu, SPJ Whelan, RH Carnahan, JE Crowe… - Cell host & …, 2021 - cell.com
Antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are being developed
as therapeutics and are a major contributor to neutralizing antibody responses elicited …

[HTML][HTML] Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children

…, KM Edwards, PF Wright, JE Crowe Jr - … England Journal of …, 2004 - Mass Medical Soc
Background We sought to determine the role of human metapneumovirus in lower
respiratory tract illness in previously healthy infants and children. Methods We tested nasal-wash …

[HTML][HTML] Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19

…, MS Diamond, RH Carnahan, JE Crowe Jr… - Nature …, 2020 - nature.com
A wide spectrum of clinical manifestations has become a hallmark of the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 pandemic, although the …

[HTML][HTML] Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

…, MS Diamond, RH Carnahan, JE Crowe Jr - Nature medicine, 2020 - nature.com
Antibodies are a principal determinant of immunity for most RNA viruses and have promise
to reduce infection or disease during major epidemics. The novel coronavirus SARS-CoV-2 …

[HTML][HTML] Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail

…, MS Diamond, JD Bloom, JE Crowe Jr - Nature …, 2021 - nature.com
Understanding the molecular basis for immune recognition of SARS-CoV-2 spike glycoprotein
antigenic sites will inform the development of improved therapeutics. We determined the …

Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus

R Xu, DC Ekiert, JC Krause, R Hai, JE Crowe Jr… - Science, 2010 - science.org
The 2009 H1N1 swine flu is the first influenza pandemic in decades. The crystal structure of
the hemagglutinin from the A/California/04/2009 H1N1 virus shows that its antigenic structure…

The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans

…, H Andersen, RH Carnahan, JE Crowe Jr… - Science translational …, 2022 - science.org
Despite the success of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
vaccines, there remains a need for more prevention and treatment options for individuals …