User profiles for J. E. Crowe
James CroweVanderbilt University Medical Center Verified email at vanderbilt.edu Cited by 36045 |
[HTML][HTML] An infectious SARS-CoV-2 B. 1.1. 529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies
… The Crowe laboratory has received sponsored research agreements from Takeda Vaccines,
AstraZeneca and IDBiologics. Vanderbilt University has applied for patents related to two …
AstraZeneca and IDBiologics. Vanderbilt University has applied for patents related to two …
[HTML][HTML] Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the global
COVID-19 pandemic. Rapidly spreading SARS-CoV-2 variants may jeopardize newly …
COVID-19 pandemic. Rapidly spreading SARS-CoV-2 variants may jeopardize newly …
[HTML][HTML] Potently neutralizing and protective human antibodies against SARS-CoV-2
The ongoing pandemic of coronavirus disease 2019 (COVID-19), which is caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major threat to global health …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major threat to global health …
[PDF][PDF] Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition
Antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are being developed
as therapeutics and are a major contributor to neutralizing antibody responses elicited …
as therapeutics and are a major contributor to neutralizing antibody responses elicited …
[HTML][HTML] Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children
…, KM Edwards, PF Wright, JE Crowe Jr - … England Journal of …, 2004 - Mass Medical Soc
Background We sought to determine the role of human metapneumovirus in lower
respiratory tract illness in previously healthy infants and children. Methods We tested nasal-wash …
respiratory tract illness in previously healthy infants and children. Methods We tested nasal-wash …
[HTML][HTML] Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19
A wide spectrum of clinical manifestations has become a hallmark of the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 pandemic, although the …
respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 pandemic, although the …
[HTML][HTML] Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein
Antibodies are a principal determinant of immunity for most RNA viruses and have promise
to reduce infection or disease during major epidemics. The novel coronavirus SARS-CoV-2 …
to reduce infection or disease during major epidemics. The novel coronavirus SARS-CoV-2 …
[HTML][HTML] Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail
Understanding the molecular basis for immune recognition of SARS-CoV-2 spike glycoprotein
antigenic sites will inform the development of improved therapeutics. We determined the …
antigenic sites will inform the development of improved therapeutics. We determined the …
Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus
The 2009 H1N1 swine flu is the first influenza pandemic in decades. The crystal structure of
the hemagglutinin from the A/California/04/2009 H1N1 virus shows that its antigenic structure…
the hemagglutinin from the A/California/04/2009 H1N1 virus shows that its antigenic structure…
The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans
…, H Andersen, RH Carnahan, JE Crowe Jr… - Science translational …, 2022 - science.org
Despite the success of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
vaccines, there remains a need for more prevention and treatment options for individuals …
vaccines, there remains a need for more prevention and treatment options for individuals …