Amyotrophic lateral sclerosis (ALS) is a fatal degenerative motor neuron disorder. Ten percent
of cases are inherited; most involve unidentified genes. We report here 13 mutations in …

Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disorder resulting
from motor neuron death. Approximately 10% of cases are familial (FALS), typically with a …

<p>The current study examines the role of perceived adequacy of social support provided
by spouses for both marital and individual functioning. Married individuals from a college …

Mutations of the lipid phosphatase FIG4 that regulates PI(3,5)P 2 are responsible for the
recessive peripheral-nerve disorder CMT4J. We now describe nonsynonymous variants of FIG4 …

We conducted a genome-wide association study among 2,323 individuals with sporadic
amyotrophic lateral sclerosis (ALS) and 9,013 control subjects and evaluated all SNPs with P < …

Exome sequencing is an effective strategy for identifying human disease genes. However,
this methodology is difficult in late-onset diseases where limited availability of DNA from …

Amyotrophic lateral sclerosis (ALS) is a spontaneous, relentlessly progressive motor neuron
disease, usually resulting in death from respiratory failure within 3 years. Variation in the …

Recent advances in sequencing technologies and collaborative efforts have led to substantial
progress in identifying the genetic causes of amyotrophic lateral sclerosis (ALS). This …

To identify genetic factors contributing to amyotrophic lateral sclerosis (ALS), we conducted
whole-exome analyses of 1,022 index familial ALS (FALS) cases and 7,315 controls. In a …

Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of motor
neurons that results in progressive weakness and death from respiratory failure, commonly …