Cardiovascular disease is the biggest killer globally and the principal contributing factor to
the pathology is atherosclerosis; a chronic, inflammatory disorder characterized by lipid and …

Atherosclerosis is a chronic inflammatory disease that is characterized by the development
of fibrotic plaques in the arterial wall. The disease exhibits a complex aetiology and its …

The human body frequently encounters harmful bacterial pathogens and employs immune
defense mechanisms designed to counteract such pathogenic assault. In the adaptive …

The ability to decode antigen specificities encapsulated in the sequences of rearranged T-cell
receptor (TCR) genes is critical for our understanding of the adaptive immune system and …

In 2016, we started a community effort to gather and curate publicly available sequence
data acquired from T cell receptor (TCRs) with defined antigen specificities, as well as …

The development of atherosclerosis, a chronic inflammatory disease characterized by the
formation of arterial fibrotic plaques, has been shown to be reduced by IL-33 in vivo. However, …

γδ T cells are considered to be innate-like lymphocytes that respond rapidly to stress without
clonal selection and differentiation. Here we use next-generation sequencing to probe how …

… MC Gold and JE McLaren contributed equally to this paper. … McLaren, Joseph A. Reistetter,
Sue Smyk-Pearson, Kristin Ladell… MC Gold and JE McLaren contributed equally to this paper. …

The human leukocyte antigen–A2 (HLA-A2)–restricted zinc transporter 8 186–194 (ZnT8
186–194 ) and other islet epitopes elicit interferon-γ secretion by CD8 + T cells preferentially in …

The capacity of the immune system to adapt to rapidly evolving viruses is a primary feature
of effective immunity, yet its molecular basis is unclear. Here, we investigated protective HIV-1…