User profiles for J. E. Walker

John E. Walker

Medical Reserach Council
Verified email at mrc-mbu.cam.ac.uk
Cited by 55463

Distantly related sequences in the alpha‐and beta‐subunits of ATP synthase, myosin, kinases and other ATP‐requiring enzymes and a common nucleotide binding …

JE Walker, M Saraste, MJ Runswick, NJ Gay - The EMBO journal, 1982 - embopress.org
JEWalker, unpublished data). Also it seems likelythat other common constraints must
operate. One such constraintmight be related to the associations between a and (3 and other pro…

Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria

JP Abrahams, AGW Leslie, R Lutter, JE Walker - Nature, 1994 - nature.com
In the crystal structure of bovine mitochondrial F 1 -ATPase determined at 2.8 Å resolution,
the three catalytic β-subunits differ in conformation and in the bound nucleotide. The structure …

[PDF][PDF] Over-production of proteins in Escherichia coli: mutant hosts that allow synthesis of some membrane proteins and globular proteins at high levels

B Miroux, JE Walker - Journal of molecular biology, 1996 - wolfson.huji.ac.il
The Medical Research We have investigated the over-production of seven membrane
proteins in Council Laboratory of an Escherichia coli–bacteriophage T7 RNA polymerase …

Molecular architecture of the rotary motor in ATP synthase

D Stock, AGW Leslie, JE Walker - Science, 1999 - science.org
Adenosine triphosphate (ATP) synthase contains a rotary motor involved in biological energy
conversion. Its membrane-embedded F 0 sector has a rotation generator fueled by the …

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein …

…, CM Wischik, RA Crowther, JE Walker… - Proceedings of the …, 1988 - National Acad Sciences
Screening of cDNA libraries prepared from the frontal cortex of an Alzheimer disease patient
and from fetal human brain has led to isolation of the cDNA for a core protein of the paired …

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

…, MJ Runswick, R Jakes, JE Walker… - Proceedings of the …, 1988 - National Acad Sciences
A substantially enriched preparation of Alzheimer paired helical filaments (PHFs) has been
used as a starting point for biochemical studies. Pronase treatment, which strips off adhering …

The NADH: ubiquinone oxidoreductase (complex I) of respiratory chains

JE Walker - Quarterly reviews of biophysics, 1992 - cambridge.org
JE Walker, unpublished work). Since the relative amounts of these subcomplexes are not
known, the number of iron atoms calculated to be present per IP fragment should be treated …

[HTML][HTML] Bovine complex I is a complex of 45 different subunits

…, JM Skehel, RJ Shannon, J Hirst, JE Walker - Journal of Biological …, 2006 - ASBMB
Mammalian mitochondrial complex I is a multisubunit membrane-bound assembly with a
molecular mass approaching 1 MDa. By comprehensive analyses of the bovine complex and …

Bioenergetic cost of making an adenosine triphosphate molecule in animal mitochondria

…, AGW Leslie, JE Walker - Proceedings of the …, 2010 - National Acad Sciences
The catalytic domain of the F-ATPase in mitochondria protrudes into the matrix of the organelle,
and is attached to the membrane domain by central and peripheral stalks. Energy for the …

The ATP synthase: the understood, the uncertain and the unknown

JE Walker - Biochemical Society Transactions, 2013 - portlandpress.com
… and JE Walker, unpublished work). The main conclusions from this study are that, with the
possible exception of yeast F 1 -ATPase inhibited with the yeast inhibitor protein, IF 1 , the …