Recent advances in genomics and proteomics, combined with the facilitated generation and
analysis of transgenic and gene-knockout animals, have revealed new complexities in …

The rate of elimination of a pathogenic agent is of critical importance for the host and
determines the extent and consequences of the infection. Antibody production, along with the …

Since their discovery, B1 B cells’ origins and developmental pathways have eluded
characterization. In the past year, focus on B1 B cells has shifted dramatically from developmental to …

We have isolated a subclone of the mouse myeloma cell line P3-X63-Ag8 that does not express
immunoglobulin heavy or light chains. This clone X63-Ag8.653 can be used for efficient …

The rate of pathogen elimination determines the extent and consequences of an infection.
In this context, the spleen with its highly specialized lymphoid compartments plays a central …

A rat monoclonal antibody specific for immunoglobulin (Ig) heavy chain binding protein (BiP)
has allowed the examination of the association of BiP with assembling Ig precursors in …

Marginal zone (MZ) and B1 B lymphocytes participate jointly in the early immune response
against T-independent (TI) particulate antigens. Here we show that blood-derived neutrophil …

Previous work has shown that mature B cells depend upon survival signals delivered to the
cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal, …

The most J H -proximal V H gene segments are used highly preferentially to form V H DJ H
rearrangements in pre-B-cell lines. This result demonstrates that the rate at which …

Innate B and T lymphocytes are a subset of lymphocytes that express a restricted set of semi-invariant,
germ-line-encoded, autoreactive antigen receptors. Although they have long …