Cellular senescence is a cell state implicated in various physiological processes and a wide
spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence …

Ageing organisms accumulate senescent cells that are thought to contribute to body dysfunction.
Telomere shortening and damage are recognized causes of cellular senescence and …

Cellular senescence is the ultimate and irreversible loss of replicative capacity occurring in
primary somatic cell culture. It is triggered as a stereotypic response to unrepaired nuclear …

Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling,
leading to compromised lung function. Cellular senescence markers are detectable within …

… 1999), prominent among these being pro‐inflammatory secretory genes (Coppe et al,
2008) and marker genes for a retrograde response induced by mitochondrial dysfunction (Passos …

Telomeres are specialized nucleoprotein structures, which protect chromosome ends and
have been implicated in the ageing process. Telomere shortening has been shown to …

Background Senescent cells, which can release factors that cause inflammation and dysfunction,
the senescence-associated secretory phenotype (SASP), accumulate with ageing and …

Aging is an inherently stochastic process, and its hallmark is heterogeneity between
organisms, cell types, and clonal populations, even in identical environments. The replicative …

The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular
senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of …

Chronic inflammation is associated with normal and pathological ageing. Here we show that
chronic, progressive low-grade inflammation induced by knockout of the nfkb1 subunit of …