The Fe(II)- and α-ketoglutarate-dependent dioxygenases catalyze hydroxylation reactions of
considerable biomedical and environmental significance. Recently, the first oxidized iron …

Background Quantifying latently infected cells is critical to evaluate the efficacy of therapeutic
strategies aimed at reducing the size of the long-lived viral reservoir, but the low frequency …

Long-lasting, latently infected resting CD4 + T cells are the greatest obstacle to obtaining a
cure for HIV infection, as these cells can persist despite decades of treatment with …

… ki67 and CD38 expression on memory CD4 + T cells and preservation of the Tcm subset
were observed after a 7-day culture in the presence of Wnt3a and anti-CD3/CD28 (JH Brehm …

During antiretroviral therapy (ART), human immunodeficiency virus type 1 (HIV-1) persists
as a latent reservoir in CD4 + T cell subsets in central memory (T CM ), transitional memory (T …

Despite advances in the treatment of HIV infection with ART, elucidating strategies to overcome
HIV persistence, including blockade of viral reservoir establishment, maintenance, and …

Recent work indicates that mutations in the C-terminal domains of human immunodeficiency
virus type 1 (HIV-1) reverse transcriptase (RT) increase 3′-azido-3′-dideoxythymidine (…

Background. It is not known how often mutations in the connection and ribonuclease H
domains of reverse transcriptase (RT) emerge with failure of first-line antiretroviral therapy (ART) …

We recently reported that zidovudine (AZT) selected for the Q509L mutation in the ribonuclease
H (RNase H) domain of HIV-1 reverse transcriptase (RT), which increases resistance to …

Activation of the NF-κB signaling pathway by Protein Kinase C (PKC) agonists is a potent
mechanism for human immunodeficiency virus (HIV) latency disruption in vitro. However, …