Although recent genome-wide studies have provided valuable insights into the genetic basis
of human disease, they have explained relatively little of the heritability of most complex …

Phenotypic variation among organisms is central to evolutionary adaptations underlying natural
and artificial selection, and also determines individual susceptibility to common diseases…

… Nadeau … Crosby, JL, Varnum, DS & Nadeau, JH Two-hit model for sporadic congenital
anomalies in mice with the disorganization mutation. Am. J. …

Coat colors in the chestnut horse, the yellow Labrador retriever, the red fox, and one type of
yellow mouse are due to recessive alleles at the extension locus. Similarly, dominant alleles …

Linkage relationships of homologous loci in man and mouse were used to estimate the mean
length of autosomal segments conserved during evolution. Comparison of the locations of …

Many valuable animal models of human disease are known and new models are
continually being generated in existing inbred strains 1, 2. Some disease models are simple …

… Lozano for critical reading of the manuscript, and members of the Nadeau laboratory for
suggestions. Services of the Trans-NIH Mouse Initiative were used for sequencing BACs …

Chromosome substitution strains (CSSs) have been proposed as a simple and powerful
way to identify quantitative trait loci (QTLs) affecting developmental, physiological, and …

Technological advances have made possible the development of high-resolution genetic
linkage maps for the mouse. These maps in turn offer exciting prospects for understanding …

The genetic architecture of complex traits underlying physiology and disease in most organisms
remains elusive. We still know little about the number of genes that underlie these traits, …