The heart hypertrophies in response to developmental signals as well as increased workload.
Although adult-onset hypertrophy can ultimately lead to disease, cardiac hypertrophy is …

… This work was supported by an American Heart Association postdoctoral fellowship (to
JH van Berlo) and by grants from the NIH (to JD Molkentin and M. Maillet) and the Howard …

Cardiac regeneration is a rapidly evolving and controversial field of research. The identification
some 12 years ago of progenitor cells that reside within the heart spurred enthusiasm for …

… van Berlo … We acknowledge the technical assistance of Rudy Duisters and Rick van
Leeuwen and thank Dr Bianca Schrans for helping us with in situ hybridization experiments. …

If and how the heart regenerates after an injury event is highly debated. c-kit-expressing
cardiac progenitor cells have been reported as the primary source for generation of new …

This study evaluated common clinical characteristics of patients with lamin A/C gene
mutations that cause either isolated dilated cardiomyopathy or dilated cardiomyopathy in …

To the Editor: Lamin A/C gene mutations are associated with various disorders, 1 , 2 including
cardiac abnormalities characterized by atrial fibrillation, conduction-system disturbances, …

Background: N 6 -Methyladenosine (m6A) methylation is the most prevalent internal
posttranscriptional modification on mammalian mRNA. The role of m6A mRNA methylation in the …

Mitochondrial calcium ( m Ca 2+ ) has a central role in both metabolic regulation and cell
death signalling, however its role in homeostatic function and disease is controversial 1 . …

… XS Revelo and JH van Berlo are supported by grants from the National Institutes of Health
(NIH; DK122056, HL130072, and HL155993), the University of Minnesota Informatics Institute…