The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight
…, I De Vivo, DF Dinges, DJ Ebert, JI Feinberg… - Science, 2019 - science.org
INTRODUCTION To date, 559 humans have been flown into space, but long-duration (>300
days) missions are rare (n = 8 total). Long-duration missions that will take humans to Mars …
days) missions are rare (n = 8 total). Long-duration missions that will take humans to Mars …
Total synthesis of a functional designer eukaryotic chromosome
Rapid advances in DNA synthesis techniques have made it possible to engineer viruses,
biochemical pathways and assemble bacterial genomes. Here, we report the synthesis of a …
biochemical pathways and assemble bacterial genomes. Here, we report the synthesis of a …
DNA methylation of cord blood cell types: applications for mixed cell birth studies
KM Bakulski, JI Feinberg, SV Andrews, J Yang… - Epigenetics, 2016 - Taylor & Francis
Epigenome-wide association studies of disease widely use DNA methylation measured in
blood as a surrogate tissue. Cell proportions can vary between people and confound …
blood as a surrogate tissue. Cell proportions can vary between people and confound …
Association of DNA methylation differences with schizophrenia in an epigenome-wide association study
… Dr AP Feinberg and Dr Fallin cosupervised this work and contributed equally as principal …
agreement mechanism: grants 5U01MH085270 (Dr AP Feinberg), 5U01MH085264 (Dr RE Gur…
agreement mechanism: grants 5U01MH085270 (Dr AP Feinberg), 5U01MH085264 (Dr RE Gur…
Paternal sperm DNA methylation associated with early signs of autism risk in an autism-enriched cohort
JI Feinberg, KM Bakulski, AE Jaffe… - International journal …, 2015 - academic.oup.com
Background: Epigenetic mechanisms such as altered DNA methylation have been suggested
to play a role in autism, beginning with the classical association of Prader-Willi syndrome, …
to play a role in autism, beginning with the classical association of Prader-Willi syndrome, …
Prenatal particulate air pollution and DNA methylation in newborns: an epigenome-wide meta-analysis
Background: Prenatal exposure to air pollution has been associated with childhood
respiratory disease and other adverse outcomes. Epigenetics is a suggested link between …
respiratory disease and other adverse outcomes. Epigenetics is a suggested link between …
Epigenetic changes in sperm are associated with paternal and child quantitative autistic traits in an autism-enriched cohort
JI Feinberg, R Schrott, C Ladd-Acosta… - Molecular …, 2023 - nature.com
There is a need to consider paternal contributions to autism spectrum disorder (ASD) more
strongly. Autism etiology is complex, and heritability is not explained by genetics alone. …
strongly. Autism etiology is complex, and heritability is not explained by genetics alone. …
[HTML][HTML] Epigenetic marks of prenatal air pollution exposure found in multiple tissues relevant for child health
C Ladd-Acosta, JI Feinberg, SC Brown… - Environment …, 2019 - Elsevier
Background Prenatal air pollution exposure has been linked to many adverse health
conditions in the offspring. However, little is known about the mechanisms underlying these …
conditions in the offspring. However, little is known about the mechanisms underlying these …
Prenatal mercury concentration is associated with changes in DNA methylation at TCEANC2 in newborns
KM Bakulski, HJ Lee, JI Feinberg… - International journal …, 2015 - academic.oup.com
Background: Human exposure to the widespread environmental contaminant mercury is a
known risk factor for common diseases such as cancer, cardiovascular disease and …
known risk factor for common diseases such as cancer, cardiovascular disease and …
[HTML][HTML] Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked …
Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex
heritability and higher prevalence in males. The neonatal epigenome has the potential to …
heritability and higher prevalence in males. The neonatal epigenome has the potential to …