Mg 2+ shares a distinctive relationship with RNA, playing important and specific roles in the
folding and function of essentially all large RNAs. Here we use theory and experiment to …

Ancient components of the ribosome, inferred from a consensus of previous work, were
constructed in silico , in vitro and in vivo . The resulting model of the ancestral ribosome …

Satellite tobacco mosaic virus (STMV) is a T = 1 icosahedral virus with a single-stranded
RNA genome. It is widely accepted that the RNA genome plays an important structural role …

Fibrin polymerizes via noncovalent and dynamic association of thrombin-exposed “knobs”
with complementary “holes.” Synthetic knob peptides have received significant interest as a …

The three-dimensional structure of the ribosomal large subunit (LSU) reveals a single
morphological element, although the 23S rRNA is contained in six secondary structure domains. …

DNA can be used as a structural component in the process of making conductive polymers
called nanowires. Accurate molecular models could lead to a better understanding of how to …

Patel A, Gossett JJ, Benton T, Rowell E, Russell H, Cham E, Pahl E. Fulminant Clostridium
difficile toxic megacolon in a pediatric heart transplant recipient. Pediatr Transplantation 2010…

We review existing methods for the analysis of RNA-Seq data and place them in a common
framework of a sequence of tasks that are usually part of the process. We show that many …

Some small icosahedral RNA viruses (eg, MS2) require a specific packaging signal for the
formation of virus particles. Others (eg, cowpea chlorotic mottle virus (CCMV); Pariacoto virus (…

This thesis covers a wide variety of projects within the domain of computational structural
biology. Structural biology is concerned with the molecular structure of proteins and nucleic …