Germ cells possess the extraordinary and unique capacity to give rise to a new organism and
create an enduring link between all generations. To acquire this property, primordial germ …

Mouse primordial germ cells (PGCs) undergo sequential epigenetic changes and genome-wide
DNA demethylation to reset the epigenome for totipotency. Here, we demonstrate that …

Facultative heterochromatin (fHC) concerns the developmentally regulated heterochromatinization
of different regions of the genome and, in the case of the mammalian X chromosome …

During development, the precise relationships between transcription and chromatin
modifications often remain unclear. We use the X chromosome inactivation (XCI) paradigm to …

Nanog, a core pluripotency factor in the inner cell mass of blastocysts, is also expressed in
unipotent primordial germ cells (PGCs) in mice 1 , where its precise role is yet unclear 2 , 3 , 4 …

Xist represents a paradigm for the function of long non-coding RNA in epigenetic regulation,
although how it mediates X-chromosome inactivation (XCI) remains largely unexplained. …

Primordial germ cells (PGCs) and preimplantation embryos undergo epigenetic reprogramming,
which includes comprehensive DNA demethylation. We found that PRMT5, an arginine …

10.7554/eLife.09571.001 Early mouse development is accompanied by dynamic changes
in chromatin modifications, including G9a-mediated histone H3 lysine 9 dimethylation (…

Xist RNA has been established as the master regulator of X‐chromosome inactivation ( XCI
) in female eutherian mammals, but its mechanism of action remains unclear. By creating …

10.7554/eLife.22345.001 The maternal-to-zygotic transition (MZT) marks the period when the
embryonic genome is activated and acquires control of development. Maternally inherited …