User profiles for J. K. Kolls
Jay KollsProfessor of Medicine and Pediatrics, Tulane School of Medicine Verified email at tulane.edu Cited by 65416 |
[PDF][PDF] Interleukin-17 family members and inflammation
JK Kolls, A Lindén - Immunity, 2004 - cell.com
IL-17A was cloned more than 10 years ago and six IL-17 family members (IL-17A-F) have
subsequently been described. IL-17A is largely produced by activated memory T lymphocytes …
subsequently been described. IL-17A is largely produced by activated memory T lymphocytes …
[PDF][PDF] The biological functions of T helper 17 cell effector cytokines in inflammation
T helper 17 (Th17) cells belong to a recently identified T helper subset, in addition to the
traditional Th1 and Th2 subsets. These cells are characterized as preferential producers of …
traditional Th1 and Th2 subsets. These cells are characterized as preferential producers of …
Targeting IL-17 and TH17 cells in chronic inflammation
P Miossec, JK Kolls - Nature reviews Drug discovery, 2012 - nature.com
The key role of interleukin-17 (IL-17) and T helper 17 (T H 17) cells in tissue inflammation,
autoimmunity and host defence led to the experimental targeting of these molecules in mouse …
autoimmunity and host defence led to the experimental targeting of these molecules in mouse …
Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host …
Bacterial pneumonia is an increasing complication of HIV infection and inversely correlates
with the CD4 + lymphocyte count. Interleukin (IL)-17 is a cytokine produced principally by …
with the CD4 + lymphocyte count. Interleukin (IL)-17 is a cytokine produced principally by …
IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia
…, MM Myerburg, CA Mason, Y Iwakura, JK Kolls - Nature medicine, 2008 - nature.com
Emerging evidence supports the concept that T helper type 17 (T H 17) cells, in addition to
mediating autoimmunity, have key roles in mucosal immunity against extracellular pathogens. …
mediating autoimmunity, have key roles in mucosal immunity against extracellular pathogens. …
TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice
Steroid-resistant asthma comprises an important source of morbidity in patient populations.
TH 17 cells represent a distinct population of CD4+ Th cells that mediate neutrophilic …
TH 17 cells represent a distinct population of CD4+ Th cells that mediate neutrophilic …
A protective function for interleukin 17A in T cell–mediated intestinal inflammation
Interleukin 23 (IL-23) and IL-17 have been linked to the pathogenesis of several chronic
inflammatory disorders, including inflammatory bowel disease. Yet as an important function for IL…
inflammatory disorders, including inflammatory bowel disease. Yet as an important function for IL…
Interleukin 17–producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice
Interleukin 17 (IL-17) is a cytokine associated with inflammation, autoimmunity and defense
against some bacteria. Here we show that IL-17 can promote autoimmune disease through a …
against some bacteria. Here we show that IL-17 can promote autoimmune disease through a …
Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae
Interleukin (IL)-23 is a heterodimeric cytokine that shares the identical p40 subunit as IL-12
but exhibits a unique p19 subunit similar to IL-12 p35. IL-12/23 p40, interferon γ (IFN-γ), and …
but exhibits a unique p19 subunit similar to IL-12 p35. IL-12/23 p40, interferon γ (IFN-γ), and …
IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis
…, T Hishinuma, J Goto, MT Lotze, JK Kolls… - The Journal of …, 2005 - journals.aai.org
In this study, we examined the biological action of IL-17 on human non-small cell lung
cancer (NSCLC). Although IL-17 had no direct effect on the in vitro growth rate of NSCLC, IL-17 …
cancer (NSCLC). Although IL-17 had no direct effect on the in vitro growth rate of NSCLC, IL-17 …