Functional impact of global rare copy number variation in autism spectrum disorders

…, H Hakonarson, EA Heron, M Hill, R Holt, JL Howe… - Nature, 2010 - nature.com
The autism spectrum disorders (ASDs) are a group of conditions characterized by impairments
in reciprocal social interaction and communication, and the presence of restricted and …

[PDF][PDF] Convergence of genes and cellular pathways dysregulated in autism spectrum disorders

…, TR Magalhaes, JK Lowe, JL Howe… - The American Journal of …, 2014 - cell.com
Rare copy-number variation (CNV) is an important source of risk for autism spectrum
disorders (ASDs). We analyzed 2,446 ASD-affected families and confirmed an excess of genic …

A genome-wide scan for common alleles affecting risk for autism

…, EA Heron, M Hill, R Holt, JL Howe… - Human molecular …, 2010 - academic.oup.com
Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the
known genetic risk has been traced to rare variants, principally copy number variants (CNVs). …

Individual common variants exert weak effects on the risk for autism spectrum disorders

…, SJ Guter, EA Heron, R Holt, JL Howe… - Human molecular …, 2012 - academic.oup.com
While it is apparent that rare variation can play an important role in the genetic architecture
of autism spectrum disorders (ASDs), the contribution of common variation to the risk of …

Whole-genome sequencing of quartet families with autism spectrum disorder

…, MJ Gazzellone, L D'abate, E Deneault, JL Howe… - Nature medicine, 2015 - nature.com
Autism spectrum disorder (ASD) is genetically heterogeneous, with evidence for hundreds
of susceptibility loci. Previous microarray and exome-sequencing studies have examined …

[PDF][PDF] Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing

…, MT Carter, C Chrysler, IE Drmic, JL Howe… - The American Journal of …, 2013 - cell.com
Autism Spectrum Disorder (ASD) demonstrates high heritability and familial clustering, yet
the genetic causes remain only partially understood as a result of extensive clinical and …

Molecular diagnostic yield of chromosomal microarray analysis and whole-exome sequencing in children with autism spectrum disorder

…, E Anagnostou, Z Wang, J Wei, JL Howe… - Jama, 2015 - jamanetwork.com
Importance The use of genome-wide tests to provide molecular diagnosis for individuals with
autism spectrum disorder (ASD) requires more study. Objective To perform chromosomal …

Rare copy number variation discovery and cross-disorder comparisons identify risk genes for ADHD

…, M Gazzellone, AR Carson, JL Howe… - Science translational …, 2011 - science.org
Attention deficit hyperactivity disorder (ADHD) is a common and persistent condition
characterized by developmentally atypical and impairing inattention, hyperactivity, and …

Genomic architecture of autism from comprehensive whole-genome sequence annotation

…, AJS Chan, W Engchuan, EJ Higginbotham, JL Howe… - Cell, 2022 - cell.com
Fully understanding autism spectrum disorder (ASD) genetics requires whole-genome
sequencing (WGS). We present the latest release of the Autism Speaks MSSNG resource, which …

Attitudes toward working on interdisciplinary healthcare teams: a comparison by discipline

…, S Fairchild, CK Cassel, JL Howe - Journal of the …, 2002 - Wiley Online Library
Interdisciplinary teams are important in providing care for older patients, but interdisciplinary
teamwork is rarely a teaching focus, and little is known about trainees' attitudes towards it. …