The central dogma of gene expression is that DNA is transcribed into messenger RNAs, which
in turn serve as the template for protein synthesis. The discovery of extensive transcription …

Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term ‘lncRNAs’ encompasses RNA polymerase I (Pol I), Pol II …

It is clear that RNA has a diverse set of functions and is more than just a messenger between
gene and protein. The mammalian genome is extensively transcribed, giving rise to …

Recent advances in high-throughput cDNA sequencing (RNA-seq) can reveal new genes
and splice variants and quantify expression genome-wide in a single assay. The volume and …

Noncoding RNAs (ncRNA) participate in epigenetic regulation but are poorly understood.
Here we characterize the transcriptional landscape of the four human HOX loci at five base …

Large intervening non-coding RNAs (lincRNAs) are pervasively transcribed in the genome 1
, 2 , 3 yet their potential involvement in human disease is not well understood 4 , 5 . Recent …

Defining the transcriptional dynamics of a temporal process such as cell differentiation is
challenging owing to the high variability in gene expression between individual cells. Time-…

There is growing recognition that mammalian cells produce many thousands of large intergenic
transcripts 1 , 2 , 3 , 4 . However, the functional significance of these transcripts has been …

Large intergenic noncoding RNAs (lincRNAs) are emerging as key regulators of diverse
cellular processes. Determining the function of individual lincRNAs remains a challenge. …

Differential analysis of gene and transcript expression using high-throughput RNA sequencing
(RNA-seq) is complicated by several sources of measurement variability and poses …