Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together
with polygenetic risk stratification can contribute towards planning of feasible and efficient …

DNA sequencing has markedly changed the nature of biomedical research, identifying millions
of polymorphisms along the human genome that now require further analysis to study the …

Importance An estimated 40% of dementia is potentially preventable by modifying 12 risk
factors throughout the life course. However, robust evidence for most of these risk factors is …

Introduction Vitamin-D plays a role regulating the immune response against to viral infection.
In this sense, vitamin-D deficiency may confer increased susceptibility to enveloped virus …

Specific regulatory states, ie, sets of expressed transcription factors, define the gene expression
capabilities of cells in animal development. Here we explore the functional significance …

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in
over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) …

Abstract Systems allowing tightly regulated expression of prokaryotic genes in vivo are
important for performing functional studies of bacterial genes in host-pathogen interactions and …

Background: Hepatic encephalopathy is a major complication of cirrhosis and is associated
with a poor prognosis. Objective: To identify mutations in the gene sequence for glutaminase …

Importance TheAPOEε2 andAPOEε4 alleles are the strongest protective and risk-increasing,
respectively, genetic variants for late-onset Alzheimer disease (AD). However, the …

Background SHOX, located in the pseudoautosomal region 1 (PAR1) of the sexual
chromosomes, encodes a transcription factor implicated in human growth. Defects in SHOX or its …