Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has fueled
remarkable advances in our understanding of its potential neurobiological mechanisms. …

MicroRNAs (miRNAs) repress cellular protein levels to provide a sophisticated parameter of
gene regulation that coordinates a broad spectrum of biological processes. Bone …

We present an overview of Runx involvement in regulatory mechanisms that are requisite
for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the …

Multiple studies have confirmed the contribution of rare de novo copy number variations to
the risk for autism spectrum disorders 1 , 2 , 3 . But whereas de novo single nucleotide …

Both activating and null mutations of proteins required for canonical WNT signaling have
revealed the importance of this pathway for normal skeletal development. However, tissue-…

Identifying genetic variants influencing human brain structures may reveal new biological
mechanisms underlying cognition and neuropsychiatric illness. The volume of the …

This paper develops a simple geometric technique for the simultaneous determination of
spot and futures prices in commodity markets; and it explains the allocation between hedged …

The highly complex structure of the human brain is strongly shaped by genetic influences 1 .
Subcortical brain regions form circuits with cortical areas to coordinate movement 2 , …

Bone tissue arises from mesenchymal cells induced into the osteoblast lineage by essential
transcription factors and signaling cascades. MicroRNAs regulate biological processes by …

Bone morphogenetic proteins (BMPs) are potent morphogens that activate transcriptional
programs for lineage determination. How BMP induction of a phenotype is coordinated with …