10.7554/eLife.19944.001 During apoptosis, Bak and Bax undergo major conformational
change and form symmetric dimers that coalesce to perforate the mitochondrial outer …

Apoptotic stimuli activate and oligomerize the proapoptotic proteins Bak and Bax, resulting in
mitochondrial outer-membrane permeabilization and subsequent cell death. This activation …

Neonicotinoid insecticides have come under increasing scrutiny for their impact on non-target
organisms, especially pollinators. The current scientific literature is mainly focused on the …

BAK and BAX are essential mediators of apoptosis that oligomerize in response to death
cues, thereby causing permeabilization of the mitochondrial outer membrane. Their transition …

The E3 ubiquitin ligase Parkin is a key effector of the removal of damaged mitochondria by
mitophagy. Parkin determines cell fate in response to mitochondrial damage, with its loss …

… Brouwer et al. describe the first crystal structures of BH3-only peptides bound to Bak, which
reveal a cavity that may be important for activation. They then use structure-based design to …

A body of data supports the existence of core (α2–α5) dimers of BAK and BAX in the
oligomeric, membrane-perturbing conformation of these essential apoptotic effector molecules. …

Twister™ is a revolutionary gas conditioning technology which has been under development
for natural gas applications since 1997. Condensation and separation at supersonic …

Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated
approach to cancer therapy. In contrast, blocking apoptosis to prevent the death of healthy …

The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
had a large impact on global health, travel, and economy. Therefore, preventative and …